null Melanosome transport inhibition for the treatment of melanoma

This invention relates to methods of increased the sensitivity of cancers, such as melanoma, to cytotoxic anti-cancer compounds, such as methotrexate, by inhibiting melanosome trafficking in the cancer cells, for example using Akt2 signalling inhibitors, such as 7-hydroxystraurosporine. Methods of treatment and compounds for use therein are provided.


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