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null Antifolate compounds for the treatment of melanoma

This invention relates to compounds of the formula X) or Xl) (X) (XI) wherein: each -R1, -R2 and -R3 is independently -Q1, -OH or -H, where at least one of -R1, -R2 and -R3 is not -H or -OH; each -R4 and -R5 is independently -Q2 or -H; each -Q1 is independently selected from: -F, -Cl, -RA, -ORA,-SH, -SRA, where each -RA is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups; and each -Q2 is selected from: -F, -Cl, -RB, -ORB, -SH, -SRB, where each -RB is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups; which are useful in the treatment of melanoma.

 

antifolate

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Antifolate compounds for the treatment of melanoma