Escuela Internacional de Doctorado

Coordination

 

PhD. Victoriano Garre Mula

coordbmbt@um.es

Tel.: +34 868 88 7148

Fax: +34 868 88 3963

 

General Information

Presentation

The PhD Program in Molecular Biology and Biotechnology is the adaptation of a previous one with the same name and taught for many years, until it was adapted to fit the regulations included in Royal Decree 99/2011. The high quality scientific-training it provides justifies the Quality Mention the programme obtained in 2004 for the first time, as well as the subsequent renewals of this mention until it was, in 2011, awarded the Mention towards Excellence.

During the last 5 years, the research teams of the PhD Program in Molecular Biology and Biotechnology, belonging to the University of Murcia, have published more than 250 articles in indexed international journals and have conducted 42 PhD theses which, together with the theses directed by external collaborating teams, sum up to more than 50. The programme teaching staff counts on years of experience in research and in international collaboration activities.

This PhD programme has always been highly demanded. We count not only on students directly related to our research groups but also on students from other institutions, such as the Center for Edaphology and Applied Biology of the River Segura (research center depending on the CSIC), the Ministry of Agriculture, the Ministry of Health, etc. Thus, our program may be said not only to guarantee the continuity of our discipline and research groups but also to respond to a true social demand resulting from the increasingly relevant place that Biotechnology and Molecular Biology occupy in the Science-Technology-Industry-Society system.

With this programme, students are expected to become professionally qualified to develop different aspects in Bioscience. Industries in sectors like pharmacy, agro-food, biotechnology, health, environmental engineering, etc. may benefit from our graduates recruitment. The research training we offer will be demanded within a wide range of institutions, including universities, public scientific and technological research centers (such as the CSIC and other Estate Research Entities), private research centers, hospitals, analysis laboratories, and  R+D+I sections in biotechnological, sanitary and pharmaceutical companies among others. The close relationship between the program and the Biomedical sciences enables students to research on molecular mechanisms of disease and molecular approaches to the scrutiny, diagnosis, prevention and treatment of diseases, by using knowledge derived from the Molecular Sciences of Life and Applications. On the other hand, the biotechnological content of the programme allows its application to the field of Industrial Biotechnology in order to obtain products, goods and services, as well as for the management and control of biotechnological processes in industrial production plants. Other professional activities linked to this profile relate to technology transfer between basic and applied research, quality control in biotechnology laboratories and in bio-industries, the biotechnology patents we obtain and the advice and expertise in biotechnological and bio-safety aspects. Although the labour framework for these activities relates particularly to biotechnology industries, it also extends to other industries using biotechnological applications, such as the pharmaceutical, veterinary, agri-food and chemical ones, as well as those related to environment.

Programme Guidelines

  • Research teams and lines
  • Training activities
  • Training complements
  • Access profile and admission criteria
  • Academic Committee

 

Research teams and lines

Research team nº1: Biochemistry and Biotechnology Enzyme

Research team nº2: Enzymology and Neuropathologies

Research team nº3: Biomembranes

Research team nº4: Microbial Physiology and Biotechnology

Research team nº5: Medical Microbiology

Research team nº6: Molecular Genetics

Research team nº7: Genomics and Molecular Biotechnology of Funga

Research team nº8: Modeling, Processing and Knowledge Management Technologies

Research team nº9: Nonspecific Immune System of Teleosteal Fishes

Research teams with institutions, researchers and research lines outside the University.

 

 

Research Team: Biochemistry and Biotechnology Enzyme

Research line nº1: Enzymatic Biotechnology.

PhD. Francisco García Carmona. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

We research on all aspects of enzyme industrial uses: cloning and over-expression of enzymes, their purification, their adaptation to working environments by means of mutations and their stabilization with covalent modifications and immobilizations, as well as their kinetic characterization and industrial use.

 

Research line nº2: Molecular Characterization of Biomedical and Biotechnology Enzymes Related to Sirtuins and Aging.

PhD. Álvaro Sánchez Ferrer. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

We research on the discovery of new enzymes related to sirtuins by in silico analysis and metagenomic techniques, their cloning, their evolution, their molecular characterization and crystallization. We aim to find new molecules (inhibitors and activators) related to aging and neurodegenerative diseases.

 

Research line nº3: Characterization and encapsulation of bioactive compounds for use in food, pharmaceutical and cosmetic industries.

PhD. José Manuel López Nicolás. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

Due to the importance of developing new products with a clear added value for the market, in this line we research on new characterization techniques of important bioactive compounds with antioxidant, antimicrobial, antifungal capacity etc. for encapsulation; this facilitates the use of these compounds in food, pharmaceutical and cosmetics industries. Different analytical techniques such as fluorescence, chromatography, spray-dry, spectrophotometry, etc. will be used.

 

Research line nº4: Study of Bioactive Compounds.

PhD. Josefa Escribano Cebrián. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

A process will be developed in order to obtain betalamic acid. This molecule has high antioxidant capacity and captures free radicals. It is also the unit embedded in all betalaines. Starting from betalamic acid as structural unit, we will obtain natural and derived molecules with food-related interest that have high biological activities. Nanoencapsulation processes will be developed to obtain and stabilize bioactive compounds.

Research line n.5: Molecular Strategies in the Production of Bioactive Compounds of Plant Origin.

PhD. Fernando Gandía Herrero. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A.

This line focuses in obtaining enzymes with relevant activities so that compounds in the secondary metabolism of plants with bioactive potential can be developed. Debates on the characterization and use of secondary metabolism reactions of plants are encouraged, as well as on the cloning, expression and characterization of the key enzymes of studied routes. The obtained features of compounds and intermediates are further studied for potential applications.

 

Nº: 6. Research Line: Bioactive Properties of Betalains.

PhD. Juana Cabanes Cos. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A.

We identify and study the functional abilities of the family of beta-lactam bioactive compounds. The betalains are pigments that contain nitrogen, generally soluble in water, and are restricted to Cariophylales plants. In the last decade, prospects for their application in the food industry are opening up due to the biological activity of betalain and its potentialities for human health, in the prevention of diseases related to oxidative stress.

 

Research line nº7: Stabilization of Bioactive Compounds by Microencapsulation.

PhD. Mercedes Jiménez Atiénzar. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A.

One of the major problems bioactive compounds may face is their stability. This is why their protection is necessary by encapsulating molecules such as maltodextrins and other food-use polymers. These complexes will be treated with the Spray-dry technique to obtain the microcapsules that will be characterized by means of different analytical methods. Last, the microcapsules stability over time will be assessed against agents such as light and temperature.

 

Research line nº 8: Characterization of Fungal Enzymes.

PhD. Manuela Pérez Gilabert. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

This line of research is currently focused on the characterization of mycorrhizal fungi enzymes. The mycorrhiza formed by Almería Helianthemum with the fungus Terfezia claveryi has been taken as a model system. This fungus produces hypogeal sporocarps and edible products of great commercial interest. We study the hydrolases activity in different stages of the biological cycle of T. Claveryi and their role in the nutrition of their host plant.

 

Research Team: Enzymology and Neuropathologies

Research line nº9: Role of Cholinesterases in Cell Proliferation.

PhD. Cecilio Jesús Vidal Moreno

PhD. Encarnación Muñoz Delgado

PhD. Francisco Javier Campoy Menéndez

University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

We manipulate the cholinergic operator to check how and to what extent tumorogenesis is affected. We analyse: 1) acetylcholinesterase (AChE) and butyrylcholinesterase activity, AChE / BuChE protein content, number of AChE / BuChE transcripts, number of mRNAs for muscarinic receptors, and nicotinic receptor alpha-7 subunit in intestinal (Caco2, HT29, and others) and renal (ACHN and CAKI2) cells; 2) changes in these magnitudes when the cells differentiate or enter into apoptosis; 3) the effect of silencing or overexpression of ACHE and BUCHE genes on cell proliferation, differentiation and apoptosis.

Nº: 10. Research Line: Cholinesterases in Pathologies.

PhD. Cecilio Jesús Vidal Moreno

PhD. Encarnación Muñoz Delgado

PhD. Francisco Javier Campoy Menéndez

University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

We study: 1) changes in the expression of ACHE and BUCHE genes in muscles, peripheral nerves, heart and other organs in mice with muscular dystrophy caused by merosin deficiency; 2) variation in the expression of nicotinic receptors; 3) the role and changes of AChE in lipid rafts. 4) the AChE / amyloid / presenilin ratio and its implication in Alzheimer's; 5) changes in the expression of ACHE and BUCHE genes in the hippocampus and the cerebral cortex in mutant mice for tau protein, with cognitive deficit; 6) changes in the expression and molecular properties of cholinesterases linked to the development of tumors.

 

Research line nº 11: Tumor Resistance to Drugs and Development of New Antitumor Molecules

PhD. José Neptuno Rodríguez López. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

Our research work focuses on studies of antitumor resistance mechanisms to various drug types and development of new natural and synthetic drugs for the treatment of melanoma and other epithelial cancers. New dihydrofolate reductase inhibitors are developed based on the structure of the tea catechins. The research line has a strong translational nature and the studies range from the laboratory to their clinical use. (Www.um.es/genz).

 

Research line nº12: Enzyme Regulation, Epidermal Depigmentation and Tyrosinase Reaction Mechanism

PhD. Francisco García Cánovas. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

The line includes the characterization of the tyrosinase reaction mechanism of various biological sources and the development of this enzyme inhibitors based on structure-function studies. The development and study of these inhibitors will be applied to the generation of new epidermal depigmenting agents and their use in biotechnological processes. (Www.um.es/genz).

 

Research line nº13: Biotechnological Applications of Nutraceutical and Cosmeceutical Enzymes and Biomolecules.

PhD. José Tudela Serrano, Department of Biochemistry and Molecular Biology-A

PhD. Virginia Tomás Martínez, Department of Analytical Chemistry

University/Institution: University of Murcia

Enzymes and production, stabilization and biotechnological applications of organic and cosmeceutical functional biomolecules, derived from aromatic and medicinal plants, algae, funga and agroindustrial fruit and vegetable wastes. Analytical (GC-MS, UHPLC-MS) and preparative (Prep-FPLC, Prep-HPLC) proteomics and metabolomics. Molecular and cellular bioactivity of antioxidants and other nutricutical and cosmeceutical biomolecules. Research with pharmaceutical, cosmetic, food and chemical biotechnology companies. (Www.um.es/genz).

 

Research Team Biomembranes

Research line nº14: Transmission of Cellular Signals through Proteines Kinasas C.

PhD. Senna Corbalán García. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

Recent research works carried out by this team have shown that the C2 domain of classical PKC interacts specifically with two plasma membrane phospholipids: phosphatidylserine and phosphatidylinositol-bisphosphate. However, the importance of these interactions in cell biology or pathological processes is not determined. The objectives of our study are: a) to characterize the molecular interactions of the different C2 domains with membranes, and to study their function using different cell lines; B) generate different interaction maps of PKCs and other proteins containing C2 domains regulated by phosphatidylinositols by the use of proteomic techniques.

 

Nº: 15. Research Line: Structural and Functional Characterization of Proteins with C2 Domains.

PhD. Senna Corbalán García. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

Recent research works carried out by this team have shown that the C2 domain of classical PKC interacts specifically with two plasma membrane phospholipids: phosphatidylserine and phosphatidylinositol-bisphosphate. However, the importance of these interactions at the level of cell biology or pathological processes is not determined. The objectives of our study are: a) to characterize the molecular interactions of the different C2 domains with membranes, and to study their function using different cell lines; B) generate different interaction maps of PKCs and other proteins containing C2 domains regulated by phosphatidylinositols by the use of proteomic techniques.

Research Team: Microbial Physiology and Biotechnology

Research line nº16: Study of the Function of Proteines Kinasas C in Cancer.

PhD. Senna Corbalán García. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

Taking into account the wide variety of PKC isoenzymes in the same cell type or tissue, they could be used as tuners in those cellular signal transmission pathways that control the oncogenic process. However, a better characterization of these proteines function and regulation is necessary. Current studies are focused on: a) identifying the signal transmission pathways activated by the different PKC isoenzymes; B) identify the differential expression of key proteins that are down-regulated by PKC activation.

 

Research line nº17: Lipid-Protein Interaction in Cell Signaling.

PhD. Juan Carmelo Gómez Fernández. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

Proteins involved in cell signaling are studied, paying special attention to proteins Kinases C and their activation by interaction with lipids in the membranes.

 

Research line nº18: Molecular Interactions in Membranes.

PhD. José Antonio Teruel Puche

PhD. Francisco José Aranda Martínez.

University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

This line studies the effect of biologically active compounds on the membrane structure and function, using both biological membranes and membrane models. In order to get to know the action molecular mechanism of these compounds on the membrane, biophysical techniques such as differential scanning calorimetry, fluorescence and infrared spectroscopy and X-ray diffraction are used.

 

Research line nº19: Biological Surfactants: Production, Properties and Biotechnological Applications.

PhD. Antonio Ortíz López. University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

Microorganisms produce complex mixtures of surfactants (biotensioactive or biological surfactants), of great structural diversity, molecular size and chemical properties, being able to compete in the future in their applications with synthetic surfactants, especially in the food, cosmetics, biomedicine, bioremediation and agriculture industries. This line addresses the identification of new biotensioactives, their structural determination and the characterization of their physicochemical and biological properties, mainly in relation to the modulation of the properties of phospholipid membranes and the enzymatic activity.

Research line nº 20: Ca2 + -ATPasa of SERCA Type: Intracellular Control of Ca2 + and Cell Damage Induced by Ca2 + in Cardiac Cells.

PhD. Francisco Fernández Belda

PhD. Fernando Soler Pardo

University/Institution: University of Murcia. Department: Biochemistry and Molecular Biology-A

The intracellular signal that induces cardiac contraction is Ca2 + coming from sarcoplasmic reticulum. When Ca2 + -ATPasa (SERCA) pumps Ca2 + into the reticulum to recover the basal level of cytosolic Ca2 +, relaxation is induced. SERCA alterations modify the heart mechanical and electrical properties. The objective is to characterize the effect of molecules that interfere with the SERCA function and to analyze the intracellular alterations of Ca2 + and its consequences on cell death and damage.

 

Research Team: Microbial Physiology and Biotechnology

Research line nº 21: Regulation of Cell Integrity in Eukaryotic Microorganisms.

PhD. José Cansado Vizoso

PhD. Alejandro Franco Sánchez

University/Institution: University of Murcia. Department: Genetics and Microbiology

Study of the molecular bases that regulate morphogenesis and cell size in simple eukaryotes, focusing on yeast models. Routes of signal transmission mediated by MAP kinases, GTPasas, etc., and their role in the control of cell polarity and shape. Http://www.um.es/gr-fisiologia/en/

Research line nº22: Control of Sexual Differentiation in Eukaryotic Microorganisms.

PhD. Mariano J. Gacto Fernández

University/Institution: University of Murcia. Department: Genetics and Microbiology

Characterization of the role of MAP kinases routes in the sexual development (conjugation, meiosis) of different yeast species. Interaction (crosstalk) between MAP kinase routes. Http://www.um.es/gr-fisiologia/en/

 

Research line nº23: MAP Kinases and Response to Stress.

PhD. Teresa Soto Pino

PhD. María Isabel Madrid Mateo

University/Institution: University of Murcia. Department: Genetics and Microbiology

Modules of MAP kinases and their role as signal integrators in response to different environmental stress situations (osmotic stress, thermal shock, oxidative stress, nutritional stress). Characterization of activators and identification of their molecular targets. Http://www.um.es/gr-fisiologia/en/

 

Research line nº24: Response Metabolites to Stress in Eukaryotic Microorganisms.

PhD. Jerónimo Vicente Soler. University/Institution: University of Murcia. Department: Genetics and Microbiology

Biological role of different organic compounds (trehalosa, glycerol, other compatible solutes), in the cellular defense against different types of stress. Http://www.um.es/gr-fisiologia/en/

Research line nº25: Molecular Biology of the Synthesis of L-Amino Acid Oxidases in Bacteria.

PhD. Antonio Sánchez Amat. University/Institution: University of Murcia. Department: Genetics and Microbiology

L-amino acid oxidases (LAOs) are enzymes that oxidize L-amino acids by generating the corresponding ketoacid, ammonium and hydrogen peroxide, which gives them antimicrobial properties. These enzymes have biotechnological interest in processes such as biotransformations. The diversity of LAOs in bacteria is our research topic. In this line, we have described a new LAO with L-lysine-ε-oxidase activity (EC 1.4.3.20). This enzyme has a quinone cofactor unlike the previously described LAOs that are flavoproteins. Http://www.um.es/biotecmicrob/

 

Research line nº26: Regulation of the Expression of Oxidase Activities in Bacteria.

PhD. Patricia Lucas Elío. University/Institution: University of Murcia. Department: Genetics and Microbiology

The marine bacterium Marinomonas Mediterranea, the working model in our research group, shows at least 3 oxidase activities: tyrosinase, responsible for the synthesis of melanins, laccase and L-lysine-ε-oxidase. These three activities are regulated by a two component system consisting of a membrane sensing histidine kinase, PpoS, which could interact with PpoR, a response regulator. The aim of this line is to study the regulation mediated by the PpoS-PpoR system and its intracytoplasmic effectors. Http://www.um.es/biotecmicrob/

Nº 27. Research Line: Basic and Applied Microbial Ecology. Microbiology of Aquatic Media.

PhD. Francisco Torrella Mateu. University/Institution: University of Murcia. Department: Genetics and Microbiology

Basic and applied research in microbiology has focused on the following fields of work, supported by specific projects: Microbiology of biological systems for wastewater treatment. Microbiology of wastewater reuse in agriculture; Marine microbiology (survival and adaptation of marine bacteria to the environment); Microbiology of composting of oil by-products (alperujo), microbial diversity in extreme halophilic environments: solar saline, production of mycotoxins (ochratoxin) by fungi of paprika and grapes for winemaking, morphology and ultrastructure of microorganisms: optical and electronic microscopy.

 

Research team: Medical Microbiology

Research line nº 28: Mycobacterium Cell Envelope Lipids.

PhD. Pedro Luis Valero Guillén. University/Institution: University of Murcia. Department: Genetics and Microbiology

The cellular envelope of mycobacteria is rich in lipids and is related to the pathogenesis of tuberculosis and mycobacteriosis. In this line of research, our major interest is to study the structure/function relationship of various glycolipids of mycobacteria and, essentially, their immuno-modulating activity, as a preliminary step for their consideration as adjuvants of protein vaccines against tuberculosis.

 

Research line nº29: Molecular Characterization of Mechanisms of Pathogenicity and Resistance to Antibiotics in Microorganisms of Medical Relevance.

PhD. Genoveva Yagüe Guirao

PhD. Manuel Segovia Hernández

University/Institution: University of Murcia. Department: Genetics and Microbiology

The molecular bases of virulence and resistance to antibiotics in medically relevant clinical isolates are analyzed as a basis for the control of common and emerging microorganisms in different intra- and extra-hospital infectious diseases.

 

Research team: Molecular Genetics

Research line nº30: Bacterial Molecular Genetics I: Global and Specific Regulation of Gene Expression in Bacteria.

PhD. Monserrat Elías Arnanz

PhD. Marta Fontes Bastos

PhD. María del Carmen Polanco de la Puente

University/Institution: University of Murcia. Department: Genetics and Microbiology

PhD. Subramaniam Padmanabhan Iyer. University/Research Center: Institute of Physical Chemistry "Rocasolano", CSIC, Madrid. Department of Chemistry-Physics-Biology

A central problem in biology is to understand the regulation of specific genes during normal development or in response to environmental stimuli. In bacteria, faced with continuous environmental changes and stress situations, such regulation is usually produced by proteins that activate or repress gene transcription. It goes on defining the mode of action and physiological effects of some of these bacterial proteins that either regulate a few genes or act as regulators (global) of many different genes. Http://www.um.es/myxoum/MyxoUM/Inicio.html

Research line nº31: Bacterial Molecular Genetics II: Chromosomal Segregation and Other Essential Cell Processes.

PhD. Monserrat Elías Arnanz

PhD. Antonio Ángel Iniesta Martínez

PhD. Marta Fontes Bastos

PhD. Mª Carmen Polanco de la Puente

PhD. Subramanian Padmanabhan Iyer

University/Institution: University of Murcia. Department: Genetics and Microbiology

Our overall objective is to understand the keys to segregation and organization of the bacterial chromosome, using the bacterium Myxococcus xanthus as a model, as well as the study of other processes that are essential for cell viability. Http://www.um.es/myxoum/MyxoUM/Inicio.html

Research team: Genomics and Molecular Biotechnology of Fungi

Research line: Gene Silencing in Filamentous Mushrooms.

PhD. Rosa María Ruiz Vázquez

PhD. Santiago Torres Martínez

PhD. Victoriano Garre Mula

PhD. Eusebio Navarro Ros

PhD. Francisco Esteban Nicolás Molina

University/Institution: University of Murcia. Department: Genetics and Microbiology

Our main objective is to research on the role of the gene silencing mechanism mediated by small non-coding RNAs in the regulation of endogenous cellular processes, such as light responses, pathogenesis and cell death induced by stress in the fungus Mucor circinelloides, an opportunist pathogen causative agent of mucormycosis. The experimental approach is based on genomic and transcriptomic analysis of mutants in the silencing genes, previously characterized by our group. Http://www.um.es/mucorgen/

 

Nº 33. Research Line: Characterization of the Molecular Mechanisms that Regulate the Responses to Light in Funga.

PhD.Victoriano Garre Mula

PhD. Eusebio Navarro Ros

PhD. Francisco Esteban Nicolás Molina

University/Institution: University of Murcia. Department: Genetics and Microbiology

This line uses genetic and genomic approaches to identify and characterize the mechanisms that control the light responses in funga, using Mucor circinelloides as a model. Thus, four regulatory genes have been identified that fulfill essential functions in these responses and participate in three distinct regulatory pathways. Current experimental strategies attempt to characterize in detail the function of already identified genes and to identify new ones that regulate the responses to light. Http://www.um.es/mucorgen/

Nº: 34. Research Line: Genetic Improvement of Oleaginous Mushrooms for Biodiesel Production.

PhD.Victoriano Garre Mula

PhD. Eusebio Navarro Ros

PhD. Francisco Esteban Nicolás Molina

University/Institution: University of Murcia. Department: Genetics and Microbiology

The failure to generate from vegetable oils the biodiesel required by society has led to the search for alternative sources, among them oil-producing microorganisms. In this line it has been proved that the Mucor circinelloides biomass can be transformed directly, without previous extraction of the oil, into high quality biodiesel. Current lines of research seek to obtain, through genetic engineering, lipid over-productive strains that may turn their lipids into biodiesel. Http://www.um.es/mucorgen/

 

Nº: 35. Research Line: Molecular Genetics of Eukaryotes.

PhD. Victoriano Garre Mula

PhD. Eusebio Navarro Ros

University/Institution: University of Murcia. Department: Genetics and Microbiology

This line includes research using superior eukaryotes, mainly plants, as model organisms in genetics, and also molecular studies of different processes, including responses to stress situations, regeneration of transformed plants, etc. This research work is carried out in collaboration with teachers outside the University of Murcia, mainly researchers of the Center for Edaphology and Applied Biology of the Segura (CEBAS-CSIC). Http://www.um.es/mucorgen/

 

Research Team: Modeling, Processing and Knowledge Management Technologies *

Nº: 36. Research Line: Bioinformatics.

PhD. Jesualdo Tomás Fernández Breis

PhD. Rafael Valencia García

Department: Computer and Systems

PhD. Rodrigo Martínez Béjar

Department: Information and Communication Engineering

University/Institution: University of Murcia

The objective is the development of computer solutions to support information management and biological knowledge as well as the resolution of biological problems. Research in this line is based on the study of how semantic technologies, natural language processing and cloud computing can improve such management processes and problem solving.

Research team: Nonspecific Immune System of Teleosteal Fishes

Nº: 37. Research Line: Evolution of the Immune Response in Vertebrates.

PhD. Victoriano Mulero Méndez

PhD. José Meseguer Peñalver

PhD. Alfonsa García Ayala

PhD. Mª Pilar Sepulcre Cortés

University/Institution: University of Murcia. Department: Cell Biology and Histology

This line focuses on the study of the teleost fish immunity from a basic (immunity evolution) and applied (aquaculture) point of view. Functional and molecular characterization of Toll-like receptors (TLRs), pro-inflammatory and antiviral cytokines, and granulocytes, macrophages and mast cells in immune-reproducing interactions are particularly sought. All this basic knowledge is used for the rational development of immune-stimulating agents and vaccines for aquaculture.

 

Nº: 38. Research Line: Immunity, Inflammation, Angiogenesis, Hematopoiesis and Cancer.

PhD. Victoriano Mulero Méndez

PhD. José Meseguer Peñalver

PhD. Mª Pilar Sepulcre Cortés

University/Institution: University of Murcia. Department: Cell Biology and Histology

This research line aims to study the impact of inflammation on angiogenesis, hematopoiesis and cancer using as a model the zebrafish. To this purpose, it is used in vivo visualization techniques of fluorescent markers, gene inactivation using morphine and Talen nucleases, and development of new transgenic lines.

Nº: 39. Research Line: Immune System of Fish and Invertebrates.

PhD. Mª Ángeles Esteban Abad

University/Institution: University of Murcia

Department: Cell Biology and Histology

We study fish and invertebrates immune systems relevant in aquaculture. It is particularly relevant for the innate immune system, the mucous membrane immunity and the enrichment of diets to make of them true functional foods. We also deepen into the interactions between immune systems and pathogens and between immune systems and the aquatic environment in which fish or invertebrates are grown.

Research teams collaborating with institutions outside the University of Murcia and related research lines:

Research team: Transport of water-Acuaporins

Nº 40. Research Line: Optimization of Water Absorption by Plants. Physiological and Molecular Studies.

PhD. Micaela Carvajal Alcaraz, Mª Carmen Martínez Ballesta and Juan José Rios Ruiz

University/Institution: CEBAS-CSIC. Department: Plant Nutrition

The study of aquaporins and their physiological influence in abiotic stress conditions has been our main objective to identify the different aquaporins in relation to functionality and regulation. We are one of the few groups in Spain devoted to the study of water channels in plants at physiological, biochemical and molecular level

Research Team: Plant Pathology

Nº 41. Line of Research: Gene Resistance to Plant Viruses.

PhD. Miguel A. Aranda Regules, Verónica Truniger, Amelia Sánchez-Pina.

University/Institution: CEBAS-CSIC. Department: Biology of Stress and Plant Pathology

Viruses are, after funga, the main plant pathogens, causing substantial economic losses and, often, serious social problems. Methods of controlling viral infections are very limited, while the use of resistant varieties is more advantageous. In our group, we worked on the identification and characterization of sources of genetic resistance to viruses, as well as their introgression in commercial varieties.

Research team: Fruit trees biotechnology

Nº 42. Research Line: Fruit Biotechnology

PhD. Lorenzo Burgos Ortiz, César Petri Serrano, Nuria Alburquerque Ferrando, José A. Hernández Cortés, Pedro Díaz Vivancos, Abel Piqueras Castillo.

University/Institution: CEBAS-CSIC. Department: Plant Improvement

-Development of an independent genotype transformation procedure in Prunus and other woody species.

 -Collection of transformed and marker-free plants.

 -Transformation of Prunus to induce resistance to sharka virus.

 -Physiological and biochemical bases of the interaction Prunus-plum pox virus: Function of antioxidative metabolism.

 -Use of environment-friendly treatments to increase tolerance to environmental stress in plants.

 -Protein expression studies.

Research Team: Plant Nutrition

No. 43. Mechanisms of Perception and Signaling Involved in Mineral Nutrition of Plants

University/Institution: CEBAS-CSIC. Department: Plant Nutrition

PhD. Vicente Martínez López, PhD. Francisco Rubio Muñoz, PhD. Francisco Pérez Alfocea, PhD. Francisco García Sánchez, PhD. Rosa Rivero Vargas.

Study of sensory and signaling mechanisms in the mineral nutrition of plants

 

Training activities

The PhD Program in Molecular Biology and Biotechnology (DBMBT) of the University of Murcia (UMU), will describe its activities through the website of the International School of Doctoral Studies of the University of Murcia (EIDUM, www.um.es/web / Eidum): www.um.es/web/eidum/contenido/estudios/doctorados/bio-molecular. Please remember that doctoral students’ main activity must be research and therefore, the time devoted to the following training activities should not exceed 5-8% of the total (around 80-100h per year).

 

ACTIVITIES OF THE INTERNATIONAL SCHOOL OF DOCTORAL STUDIES. UNIVERSITY OF MURCIA.

- LABORATORY SAFETY FOR DOCTORATES

Type: Optional

- ETHICS AND INTEGRITY IN SCIENTIFIC RESEARCH. CODES OF GOOD SCIENTIFIC PRACTICES

Type: Optional

- DESIGN OF EXPERIMENTS AND FOUNDATIONS OF DATA ANALYSIS

Type: Optional

- ELECTRONIC RESOURCES. BIBLIOGRAPHIC MANAGERS

Type: Optional

- RESEARCH METHODOLOGY: HEALTH SCIENCES

Type: Optional

- SCIENTIFIC COMMUNICATION: WRITING AND PUBLICATION OF SCIENTIFIC ARTICLES. PUBLIC PRESENTATION OF SCIENTIFIC RESULTS

Type: Optional

-LANGUAGES FOR SCIENTIFIC COMMUNICATION: ENGLISH APPLIED TO HEALTH SCIENCES

Type: Optional

Number of Hours: 50

-DISCLOSURE OF SCIENCE

Type: Optional

Number of Hours: 10

-EVALUATION OF SCIENTIFIC RESEARCH

Type: Optional

Number of Hours: 10

-ELABORATION AND FOLLOW-UP OF RESEARCH PROJECTS

Type: Optional

Number of Hours: 12

-TRANSFER OF KNOWLEDGE AND INNOVATION

Type: Optional

Number of Hours: 10

-DOCTORAL SESSIONS OF THE UNIVERSITY OF MURCIA (CAMPUS MARE NOSTRUM)

Type: Optional

Number of Hours: 25

 

THE PROGRAMME SPECIFIC ACTIVITIES

Specific Training Activities

  • Optional. Assistance to Research Seminars.
  • Mandatory. Presentation of own results in the team and bibliographic update.
  • Optional. Participation in National/International Conference.
  • Optional. (Mobility) International/National Stay in Research Centers with international prestige.

Transversal Training Activities

  • Optional. C-IDU Courses: addressed to staff contracted by the UMU with Venia docendi.

 

  • Optional. The following EIDUM courses:

 

 

  • Laboratory safety for doctoral students.
  • Ethics and integrity in scientific research. Code of Good Scientific Practices.
  • Research Methodology. Experimental sciences.
  • Languages ​​for scientific communication: English applied to Experimental Sciences.
  • Development and monitoring of research projects. Type: Optional

 

Complementary Training

Students who have completed a Master’s programme other than the "Master’s in Molecular Biology and Biotechnology" offered by the University of Murcia, and students who have a 300 credits Degree will be assessed by the Academic Commission individually and the Commission will consider the possibility of requiring supplementary training of the "Master in Molecular Biology and Biotechnology" offered by the University of Murcia (maximum 6 ECTS, in particular the subject "Molecular Biology and Biotechnology Seminars"). Please find the updated teaching guide of the subject and the list of seminars for each academic year on:

Http://www.um.es/web/biologia/contenido/estudios/masteres/biomybiotec

 

Access Profile and Admission Criteria

Access requirements

The selection and admission to the Doctoral Program in Molecular Biology and Biotechnology will be carried out by the programme Academic Commission.

Along the selection process, the Academic Commission of the Doctoral Program will take into account the criteria established in art. 8 of the Doctorate Regulations of the University of Murcia (R-42/2012), without prejudice to those specifically established by the Program, as follows:

  • For admission to the Doctoral programme, students must previously be accepted in any of the research groups responsible for the delivery of the program.
  • The Academic Commission of the Doctoral Program will also evaluate other merits: academic record, previous training and experience in research methodology, knowledge of English, etc.
  • The Academic Commission may, if deemed convenient, invite applicants to conduct a personal interview to provide the final resolution of the application in case of tied candidates and/or if further clarification on the claimed merits is required.
  • The Academic Commission will ensure students with specific educational needs resulting from disability to receive appropriate advisory and support services. The need for possible curricular adaptations, itineraries or alternative studies will be determined. To this end, the University of Murcia counts on the Personal Guidance and Advisory Service (SAOP), including a Support Unit for students with disabilities and/or special needs. This unit supports university students with physical, sensory and intellectual disabilities who request it. It tries to ensure equal conditions with the rest of students and full integration at the University of Murcia and its academic life.

According to the Regulations of the University of Murcia (R-42/2012), PhD studies may be carried out on a part-time basis. However, even when the requirements to carry out part-time studies are met, previous authorization by the Academic Commission is needed. In case of part-time studies, admission requirements and procedures will be the same as those described above and the admission and selection process will be restricted by the number of places offered by the Doctoral Program

Generally speaking, students interested in this program must have a Master's degree related to Molecular Biology, Biotechnology, Biochemistry or related subject. The following two income profiles are established:

Entry profile without training complements:

Master's programmes allowing access to this Doctoral Program without further training will be: "Master in Molecular Biology and Biotechnology" offered by the University of Murcia.

Other profiles:

Students who have completed a related Master’s programme other than the previous one or simply have a Degree of at least 300 credits, will be individually assessed by the Academic Commission that will consider the possibility of requiring additional training.

 

Generally speaking, students should have the following previous knowledge and skills:

 

  • Initiative, entrepreneurship and motivation for quality.
  • Ability to identify problems, find original solutions and apply them in a research or professional context.
  • Knowledge of working appropriately in labs with biological and chemical material including a responsible management of safety, handling and disposal of waste with respect to environment.
  • Ability to analyze, synthesise, organize, plan and communicate in Spanish and English at least at A2 level.
  • Ability to formulate judgments on the current and future ethical and social issues posed by biotechnological sciences in general.
  • Ability to update and continue studies in a self-directed and autonomous way, collecting and selecting the necessary information that allows an original research and that brings new knowledge.
  • Knowledge of the organization and function of living organisms at the cellular and molecular level; a good understanding of the biochemical complexity of living beings.
  • Knowledge of the experimental technologies and systems used in research within the field of Molecular Biology and Biotechnology.
  • Ability to apply theory to practice in the context of a research laboratory in the field of Molecular Biology and Biotechnology.
  • Knowledge of information technologies (bibliographic databases) to process scientific and technical information.
  • Ability to identify a significant issue or hypothesis on a topic or problem and formulate objectives, design and follow-up of a project to address its solution.
  • Ability to develop, exhibit and defend an original research work within the field of Molecular Biology and Biotechnology.
  • Recognize emerging and relevant areas in the field of Molecular Biology and Biotechnology.

Number of places offered: 40

 

Academic Committee

Coordinator:

    PhD. Victoriano Garre Mula

Secretary:

    PhD. Patricia Elio Lucas

Members of the board:

    PhD. Juan Carmelo Gómez Fernández

    PhD. Juana Cabanes Cos

    PhD. Victoriano Francisco Mulero Mendez

    PhD. Antonio Iniesta Martínez

    PhD. Pedro Luis Valero Guillén

    PhD. María Ángeles Pedreño García

    PhD. Jesualdo Tomás Fernández Breis

 

Representative of the International School of Doctoral Studies of the University of Murcia:

    PhD. Gregorio Sánchez Gómez