José Ruiz López

Departamento de Química Inorgánica - Universidad de Murcia




English version unitedkingdom

Publicaciones

Publicaciones más relevantes.

Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage. Ana Zamora, Catherine A. Denning, David K. Heidary, Erin Wachter, Leona A. Nease, José Ruiz y Edith C. Glazer. Dalton Trans. 2017, 46, 2165-2173. DOI: 10.1039/C6DT04405K

Highly potent extranuclear-targeted luminescent iridium(iii) antitumor agents containing benzimidazole-based ligands with a handle for functionalization. J. Yellol, S. A. Pérez, G. Yellol, J. Zajac, A. Donaire, G. Vigueras, V. Novohradsky, C. Janiak, V. Brabec, J. Ruiz, Chem. Commun., 2016, 52, 14165 - 14168. DOI: 10.1039/c6cc07909a

Antitumor Properties of Platinum(IV) Prodrug-Loaded Silk Fibroin Nanoparticles. A. Abel Lozano-Pérez, Ana L. Gil, Sergio A. Pérez,b Natalia Cutillas, Hajo Meyer, Mónica Pedreño, Salvador Aznar-Cervantes, Christoph Janiak, Jose Luis Cenis, and José Ruiz. Dalton Trans. 2015, Vol. 44, XXX. DOI: 10.1039/C5DT00378D

On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes. Gorakh S. Yellol, Antonio Donaire, Jyoti G. Yellol, Vera Vasylyeva, Christoph Janiak and José Ruiz. Chem. Commun. 2013, 49, 11533-11535. DOI: 10.1039/C3CC46239K

Novel Bis-C,N-Cyclometalated Iridium(III) Thiosemicarbazide Antitumor Complexes: Interactions with Human Serum Albumin and DNA, and Inhibition of Cathepsin B. José Ruiz, Consuelo Vicente, Concepción de Haro and Delia Bautista. Inorg. Chem. 2013, 52, 974-982. DOI: 10.1021/ic302219v

Novel C,N-chelate rhodium(III) and iridium(III) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA. José Ruiz, Venancio Rodríguez, Natalia Cutillas, Katia G. Samper, Mercè Capdevila , Òscar Palacios and Arturo Espinosa. Dalton Trans., 2012, 41, 12847-12856. DOI: 10.1039/c2dt31654d

A potent ruthenium(II) antitumor complex bearing a lipophilic levonorgestrel group. Ruiz José, Rodríguez Venancio, Cutillas Natalia, Espinosa Arturo, Hannon Michael J. Inorg. Chem. 2011; 50(18): 9164-71. DOI: 10.1021/ic201388n

Novel C,N-chelate platinum(II) antitumor complexes bearing a lipophilic ethisterone pendant.
José Ruiz, Venancio Rodríguez, Natalia Cutillas, Arturo Espinosa y Michael J. Hannon. Journal of Inorganic Biochemistry, 2011, 105, 525-531. DOI: 10.1016/j.jinorgbio.2010.12.005.

Synthesis and Antiproliferative Activity of a C,N-Cycloplatinated(II) Complex with a Potentially Intercalative Anthraquinone Pendant.
José Ruiz, Consuelo Vicente, Concepción de Haro y Arturo Espinosa. Inorg. Chem. 2011, 50, 2151–2158. DOI: dx.doi.org/10.1021/ic101526h.

η5-Cyclopentadienylpalladium(II) complexes: Synthesis, characterization and use for the vinyl addition polymerization of norbornene and the copolymerization with 5-vinyl-2-norbornene or 5-ethylidene-2-norbornene.
Frederik Blank, Jana K. Vieth, José Ruiz, Venancio Rodríguez y Christoph Janiak. Journal of Organometallic Chemistry, 2011, 696, 473-487. DOI: 10.1016/j.jorganchem.2010.08.050.

New 7-azaindole palladium and platinum complexes: crystal structures and theoretical calculations. In vitro anticancer activity of the platinum compounds.
José Ruiz, Venancio Rodríguez, Concepción de Haro, Arturo Espinosa, José Pérez y Christoph Janiak. Dalton Trans., 2010, 39, 3290-3301. DOI: 10.1039/b920854b.

A novel ruthenium(II) arene based intercalator with potent anticancer activity.
José Ruiz, Consuelo Vicente, Concepción de Haro y Delia Bautista. Dalton Trans., 2009, 5071-5073. DOI: 10.1039/b907296a.

N1-Coordination in New Palladium(II) and Platinum(II) Complexes with the Model Nucleobase 9-methylhypoxanthine: First Crystal Structure and Theoretical Calculations.
José Ruiz, Natalia Cutillas, María Dolores Villa, Gregorio López, Arturo Espinosa y Delia Bautista. Dalton Trans., 2009, 9637-9644. DOI: 10.1039/b915427b.

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1983

"Pentafluorophenyl derivatives of palladium(II) and platinum(II) with O-donor ligands"
G. López, G. García, N. Cutillas y J. Ruiz. Journal of Organometallic Chemistry , 1983, 241, 269-273.

"Chemical behaviour of tetrahydrofuran in the presence of the Pd(C6F5)2 moiety"
G. López, G. García, J. Ruiz y N. Cutillas. Journal of Organometallic Chemistry , 1983, 246, C83-C84.

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1985

"Trialkylsilyl (Hydrido) (ethylene) pentamethylcyclopentadienyl rhodium(III) complexes"
P.O. Bent, J. Ruiz, B.E. Mann, C.M. Spencer y P.M. Maitlis. J. Chem. Soc., Chem. Comm, 1985,1374-1375

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1986

"Replacement of alkyl by alkoxy on silicon attached to rhodium"
J. Ruiz y P. MaitlisJ. Chem. Soc, Chem. Comm., 1986, 862-863

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1987

"The synthesis and characterisation of di-hydrido-bis(trialkyltin)(pentamethylcyclopentadienyl)-rhodium(V) and -iridium(V) complexes and related reactions"
J. Ruiz, C.M. Spencer, B.E. Mann, B.F. Taylor y P.M. MaitlisJ. Organomet. Chem., 1987, 325, 253-260

"Binuclear rhodium and iridium complexes containing pentamethylcyclopentadienyl and pyrazolate ligands"
D. Carmona, L.A. Oro, M.P. Lamata, M.P. Puebla, J. Ruiz y P.M. Maitlis. J. Chem. Soc., Dalton Trans., 1987, 639-645

"Reactions of rhodium(V) hydrido-silyl complexes with butyl-lithium and with lithium triethylhydridoborate"
J. Ruiz, B.E. Mann, C.M. Spencer, B.F. Taylor y P.M. Maitlis. J. Chem. Soc, Dalton Trans., 1987, 1963-1966

"The synthesis and the structure determination of a novel η 6-arene rhodium(III) complex, [(Me2SiC6H5)4Rh2H2], and the synthesis of"
M.J. Fernández, M.A. Esteruelas, L.A. Oro, J.Ruiz, A.J. Smidth y P.M. Maitlis. J. Organomet. Chem., 1987, 330, 179-184

"The formation and characterisation of hydrido (η2-ethene) (tri-substituted silyl) pentamethylcylopentadienyl rhodium complexes; Intermediates in catalytic dehydrogenative silylation reactions"
J. Ruiz, P.O. Bentz, B.E. Mann, C.M. Spencer, B.F. Taylor y P.M. Maitlis. J. Chem. Soc., Dalton Trans., 1987, 2709-2713

"K2[Pd(C6F5)4]- Catalyzed cyclotrimerization of malononitrile"
G. López, G. Sánchez, G. García, J. Gálvez y J. Ruiz. Journal of Organometallic Chemistry, 1987, 321, 273-278.

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1989

"Hydroxo-organo-complexes of the nickel group elements"
G. López, G. García, J. Ruiz, G. Sánchez, J. García y C. Vicente. J. Chem. Soc., Chemical Communications, 1989, 1045-1046.

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1990

"Synthesis and structural study of neutral mononuclear and anionic binuclear 2,4,6-trifluorophenyl derivatives of palladium(II). Crystal structure of [P(CH2Ph)Ph3]2[(C6F3H2)2Pd(μ-SCN)(μ-NCS)Pd(C6F3H2)2]"
G. López, G. García, M.D. Santana, G. Sánchez, J. Ruiz, A. Hermoso, A. Vegas y M Martínez-Ripoll. J. Chem. Soc., Dalton Transactions, 1990, 1621-1626.

"Binuclear hydroxo-monopentahalophenyl complexes palladium(II)"
G. López, J. Ruiz, G. García, C. Vicente, J. M. Martí y M. D. SantanaJournal of Organometallic Chemistry, 1990, 359, C53-C55.

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1991

"Nickel-catalyzed cyclotrimerization of malononitrile. Synthesis and molecular structure of a dicyanomethanide bridged nickel(II) complex, [{Ni(C6F5)2(μ-NCCHCN)}2]2-"
G. López, G. Sánchez, G. García, J. Ruiz, J. García, M. Martínez-Ripoll, A. Vegas y J.A. Hermoso. Angewandte Chemie, International Edition in English, 1991, 30, 716-718.

"Synthesis, structural characterization, and reactivity toward some weak, protic electrophiles of [(C6F5)2Pd(μ-OH)2Pd(C6F5)2]2-"
G. López, J. Ruiz, G. García, C. Vicente, J. Casabó, E. Molins y C. Miravitlles. Inorganic Chemistry, 1991, 30, 2605-2610.

"Synthesis and reactivity of the di-μ-hydroxo-bis[bis(pentachlorophenyl) palladate(II)] ion"
G. López, J. Ruiz, G. García, J.M. Martí, G. Sánchez y J. García. Journal of Organometallic Chemistry, 1991, 412, 4355-443.

"Synthesis and reactivity towards some weak, protic acids of the di-μ-hydroxo-bis[bis(2,4,6-trifluorophenyl) palladate(II)] ion"
G. López, G. García, G. Sánchez, M.D. Santana, J. Ruiz y J. García. Inorganica Chimica Acta, 1991, 188, 195-200.

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1992

"Synthesis and Reactivity of Hydroxo-bridged Binuclear Platinum Complexes. Crystal Structure of [NBu4]2[{Pt(C6F5)2(μ-OH)}2]"
G. López, J. Ruiz, G. García, C. Vicente, J.M. Martí, J.A. Hermoso, A. Vegas y M. Martínez-Ripoll. J. Chem. Soc., Dalton Transactions, 1992, 53-58.

"Hydroxo and azolate pentafluorophenyl derivatives of nickel(II). Crystal Structure of (NBu4)2 [{Ni(C6F5)2(μ-OH)}2] and (NBu4)2 [{Ni(C6F5)2}2(μ-OH)(μ-pyrazolate)]"
G. López, G. García, G. Sánchez, J. García, J. Ruiz, J.A. Hermoso, A. Vegas y M. Martínez- Ripoll. Inorganic Chemistry, 1992, 31, 1518-1523.

"New methoxo-, Hydroxo- and pyrazolate-bridged platinum(II) complexes. Crystal Structure of (NBu4)2[{Pt(C6F5)2}2(μ-OH)(μ-dmpz)] (dmpz = 3,5-dimethylpyrazolate)"
G. López, J. Ruiz, G. García, C. Vicente, V. Rodríguez, G. Sánchez, J. Hermoso y M. Martínez-Ripoll. J. Chem. Soc., Dalton Transactions, 1992, 1681-1686.

"Synthesis of palladium(II) and platinum(II) N,N-dialkyldithiocarbamates starting from hydroxo-halophenyl complexes"
G. López, J. Ruiz, G. García, C. Vicente, J.M. Martí y V. Rodríguez. Journal of Organometallic Chemistry, 1992, 436, 121-126.

"Synthesis and characterization of mononuclear pyrazolyl complexes of palladium(II) and platinum(II). Crystal structures of [NBu4] [M(C6F5)2(pyrazole)(pyrazolate)] (M = Pd, Pt)"
G. López, J. Ruiz, C. Vicente, J.M. Martí, G. García, P.A. Chaloner, P.B. Hitchcock y R.M. Harrison. Organometallics, 1992, 11, 4090-4096.

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1993

"Synthesis and characterization of hydroxo, pyrazolate and carboxilate derivates of the PdR(PPh3) moiety (R = C6F5or C6Cl5)
J. Ruiz, C. Vicente, J.M. Martí, N. Cutillas, G. García y G. López. Journal of Organometallic Chemistry, 1993, 460, 241-248.

"Synthesis and characterization of arylamide-bridged binuclear palladium(II) complexes. Crystal structures of anti -[{Pd(C6F5)(t -BuNC)(m-NHPh)2]"
J. Ruiz, M.T. Martínez, C. Vicente, J.M. Martí, G. García, G. López, P.A. Chaloner y P.B. Hitchcock. Organometallics, 1993, 12, 4321-4326.

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1994

"Synthesis and Structural Study of [{Pd(CH2C9H6N)}2(m-O2CR)(m-X)] Complexes (R = Me or CF3; X = Hidroxide, Amide or Thiolate)"
J. Ruiz, N. Cutillas, J. Torregrosa, G. García, G. López, P.A. Chaloner, P.B. Hitchcock and R.M. Harrison. J. Chem. Soc., Dalton Transactions, 1994, 2353-2357.

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1995

"Pentahalophenyl palladium and platinum trinuclear complexes with tetrathiomolybdate and tetrathiotungstate ligands"
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. Journal of Organometallic Chemistry, 1995, 493, 77-82

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1996

"Synthesis and of binuclear bis(μ-aryloxo)complexes of palladium and platinum. Crystal structure of [NBu4][Pt(C6F5)2(OC6H4NO2-p)(CO)]."
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. Organometallics, 1996, 15, 1662-1668

Novel β-iminoenolate (or β-carbonyliminate) complexes starting from di-μ-hydroxo palladium or platinum complexes with dimethyl acetylenedicarboxylate and primary amines. Crystal structure of [NBu4][(C6F5)2Pd{N(C6H4NO2-p)C(CO2Me)CHC(O)OMe].
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. Journal of Organometallic Chemistry, 1996, 523, 23-32

Synthesis and structural study of [{Pd(C6H4CH2N(CH3)2)}2(μ-Br)(μ-X) complexes (X = hydroxide, amide or thiolate).
J. Ruiz, N. Cutillas, J. Sampedro, G. López, J. A. Hermoso, M. Martínez Ripoll. Journal of Organometallic Chemistry, 1996, 526, 67-72

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1997

Reactivity of hydroxo palladium and platinum complexes towards N-substituted salicylaldimines and β-ketoimines.
J. Ruiz, V. Rodríguez, C. Vicente y G. López. Transition Metal Chemistry, 1997, 22, 502-506

Synthesis and reactivity of [Pd2L2R2(μ-OH)2]- type complexes (L= PEt3, PPh3; R= Me, PhCH2, Ph). Crystal structure of [Pd2(PPh3)2(μ-OH)(μ-C6H4OMe-p)].
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. J. Chem. Soc., Dalton Transactions, 1997, 4271-4276

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1998

New aliphatic and aromatic thiolato-bridged complexes of palladium(II) and platinum(II)
J. Ruiz, C. Vicente, V. Rodríguez y G. López. Polyhedron, 1998, 17, 1503-1509

Reactivity of [NBu4]2[{(C6F5)2M(μ-OH)}2] (X = F or Cl; M = Pd or Pt) towards heterocyclic thiones: crystal structure of [NBu4]2[{(C6F5)2Pd(μ-h2-LL')}2] (LL' = methylimidazole-2-thiolate)
J. Ruiz, F. Florenciano, G. López, P. A. Chaloner, P.B. Hitchcock. Inorganica Chimica Acta, 1998, 281, 165-173

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1999

Reactivity of [{M(C6F5)2(μ-OH)}2]2- (M= Pd or Pt) towards aromatic amines and malononitrile
J. Ruiz, V. Rodríguez, G. López, J. Casabó, E. Molins y C. Miravitlles. Organometallics, 1999, 18, 1177-1184 Esquema

Reactivity of hydroxo complexes of palladium(II) towards nitriles: formation of carboxamide and imino ether derivatives of palladium(II).
J. Ruiz, N. Cutillas, V. Rodríguez, J. Sampedro, G. López, P.A. Chaloner y P.B. Hitchcock. J. Chem. Soc., Dalton Transactions, 1999, 2939-2946

New aryloxo allylpalladium complexes.
J. Ruiz, J.M. Martí, F. Florenciano, G. López. Polyhedron, 1999, 18, 2281-2285

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2000

Organometallic diaqua complexes of palladium(II).
J. Ruiz, F. Florenciano, C. Vicente, M.C. Ramírez de Arellano, G. López. Inorganic Chemistry Communications, 2000, 3, 73-75

New di- and trinuclear complexes with pyrazolato bridges. Crystal structures of [{(C6F5)2Pd(μ-pz)(μ-Cl)}2Pd]2- and [(C6F5)2Pd(μ-pz)2Pd(η3-C4H7)] (pz = pyrazolate)
J. Ruiz, F. Florenciano, M.A. Sánchez, G. López, M.C. Ramírez de Arellano, J. Pérez. European Journal of Inorganic Chemistry, 2000, 943-949

Synthesis and characterization of heterodinuclear thiolate complexes containing the Pd(η3-allyl)+ moiety. Crystal structure of [(dppe)Pd(μ-SC6H4Me-p)2Pd(η3-C3H5)][ClO4].
J. Ruiz, J. Giner, V. Rodríguez, G. López, J. Casabó, E. Molins y C. Miravitlles. Polyhedron, 2000, 19, 1624-1631

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2001

First complex containing a Pd2(μ2-N=CPh2)2 functional group.
J. Ruiz, V. Rodríguez, N. Cutillas, F. Florenciano, J. Pérez y G. López. Inorganic Chemistry Communications, 2001, 4, 23-25

Synthesis and characterization of chelate and bridging triazenide complexes of palladium and platinum. Stereoselective oxidative addition of chlorine or iodine to [NBu4][Pt(C6F5)2(h2-PhNNNPh)]
J. Ruiz, J. F. J. López, V. Rodríguez, J. Pérez, M.C. Ramírez de Arellano y G. López. J. Chem. Soc., Dalton Transaction, 2001, 2683-2689

Synthesis of terminal and bridging acetonyl complexes of palladium(II). Crystal structures of [{(AsPh3)(C6F5)Pd}2{μ-CH2C(O)CH3}2], [(AsPh3)(C6F5)Pd{CH2C(O)CH3}(t-BuNC)] and [(o-C6H4CH2NMe2)Pd{O,O'-CH(CO2Et)2}]
J. Ruiz, V. Rodríguez, N. Cutillas, M. Pardo, J. Pérez, G. López, P. A. Chaloner y P. B. Hitchcock. Organometallics, 2001, 20, 1973-1982 Esquema

Synthesis and reactivity of bridging and terminal hydrosulfide palladium and platinum complexes. Crystal structures of [NBu4] [{Pt(C6F5)2(μ-SH)}2], [Pt(C6F5)2(PPh3){S(H)AgPPh3}] and [Pt(C6F5)2(PPh3){S(AuPPh3)2}]
J. Ruiz, V. Rodríguez, C. Vicente,J. M. Martí, G. López y J. Pérez. Inorganic Chemistry, 2001, 40, 5354-5360 Esquema

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2002

New dimetallic palladium and platinum complexes containing the tetrakis-(1-pyrazolyl)borate ligand - Crystal structures of [{(C6F5)2Pd}2(m-pz)2B(m-pz)2]-, [{(C6F5)(t-BuNC)Pd}2(m-pz)2B(m-pz)2]+ and [{(C6F5)2Pd(m-pz)2B(m-pz)2Pd(h3-C4H7)]
J. Ruiz, F. Florenciano, V. Rodríguez, C. De Haro, G. López y J. Pérez. European Journal of Inorganic Chemistry, 2002, 2736-2743

Acetimine and 2-methyl-2-amino-4-iminopentane complexes of palladium(II)
J. Ruiz, V. Rodríguez, N. Cutillas, G. López y J. Pérez. Organometallics, 2002, 21, 4912-4918 Esquema

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2003

Ureato(1-/) complexes of palladium (II) and platinum (II). Crystal structure of [NBu4][(C6F5)2Pt{PhNC(O)NPri2}]
José Ruiz, Venancio Rodríguez, Consuelo Vicente, José Pérez , Gregorio López, Penny A. Chaloner, Peter B. Hitchcock. Inorganica Chimica Acta, 2003, 351, 114-118

Insertion Reactions into Pd-O and Pd-N Bonds: Preparation of Alkoxycarbonyl, Carbonato, Carbamato, Thiocarbamate, and Thioureide Complexes of Palladium(II)
José Ruiz, Mª Teresa Martínez, Félix Florenciano, Venancio Rodríguez y G. López. Inorganic Chemistry, 2003, 42, 3650-3661 Esquema

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2004

Insertion reactions of SO2 into Pd OR bonds: preparation of alkyl sulfito complexes of palladium(II)
J. Ruiz, M. T. Martinez, F. Florenciano, V. Rodriguez, G. Lopez, J. Perez, P. A. Chaloner, P. B. Hitchcock. J. Chem. Soc., Dalton Trans., 2004, 929-932.

Synthesis and characterization of new sulfide aggregates of the type [{Pt2(μ3-S)2(P-P)2}M(C6F5)2] (M=Ni, Pd, Pt; P-P=2PPh3, 2PMe2Ph, dppf)
J. Ruiz, V. Rodríguez, A. Pérez, G. López y D. Bautista. Journal of Organometallic Chemistry, 2004, 689, 12, 2080-2086

Synthesis and characterization of monomeric siloxo palladium(II) complexes: crystal structure of [Pd(tmeda)(C6F5)(OSiPh3)]
J. Ruiz, C. Vicente, V. Rodríguez, N. Cutillas, G. López y C. Ramírez de Arellano. Journal of Organometallic Chemistry, 2004, 689, 11, 1872-1875

New thiocarbamate and thioureate palladium and platinum complexes: synthesis and use as metalloligands. Unprecedented coordination of the thioureate ligand in [(C6F5)2Pd{μ2,η2-SC(NMe2)NPh}Pd(C6F5)(bpzm)]
J. Ruiz, V. Rodríguez, C. De Haro, J. Perez y G. López. Inorganica Chimica Acta, 2004, 357, 2331-2338

Condensation Reactions of Monomeric Hydroxo Palladium Complexes with Active Methyl and Methylene Compounds
J. Ruiz, M.Teresa Martínez, V. Rodríguez, G. López, J. Pérez, P. A. Chaloner y P. B. Hitchcock. J. Chem. Soc., Dalton Trans., 2004, 3521-3527.

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2005

Pentafluorophenyl imidato palladium(II) complexes: catalysts for Suzuki cross-coupling reactions
J. Ruiz, C. Vicente, N. Cutillas y J. Pérez. J. Chem. Soc., Dalton Trans., 2005, 1999-2006

New Palladium(II) and Platinum(II) Complexes with the Model Nucleobase 1-Methylcytosine. Antitumour Activity and Interactions with DNA.
J. Ruiz, N. Cutillas, C. Vicente, M. D. Villa, G. López, J. Lorenzo, F. X. Avilés, V. Moreno y D. Bautista. Inorg. Chem., 2005, 44, 7365-7376

Synthesis and Characterization of Heterotrinuclear Complexes of Nickel and Palladium with Pyridinecarboxylate as Bridging Ligands.
J. Ruiz, M. D. Santana, A. Lozano, C. Vicente, G. García, G. López, J. Pérez y L. García. Eur. J. Inorg. Chem., 2005, 3049-3056

Synthesis and Characterization of Monomeric Aryloxo Palladium Complexes of the Type [Pd(N-N)(OAr)(C6F5)]. Crystal structure of [Pd(tmeda)(C6F5)(OC6H4NO2-p)]
J. Ruiz , M. T. Martínez , C. Vicente, V. Rodríguez, G. López , J. Pérez, P. A. Chaloner y P. B. Hitchcock. Z. Anorg. Allg. Chem., 2005, 631, 2227-2231

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2006

Palladium(II) and Platinum(II) Organometallic Complexes with the Model Nucleobase Anions of Thymine, Uracil, and Cytosine. Antitumour Activity and Interactions with DNA of the Platinum Compounds.
J. Ruiz, J. Lorenzo, L. Sanglas, N. Cutillas, C. Vicente, M. D. Villa, F. X. Avilés, G. López, V. Moreno, J. Pérez y D. Bautista. Inorg. Chem., 2006, 45, 6347-6360

Can a single C-H×××F hydrogen bond make a difference? Assessing the H×××F bond strength from 2-D 1H-19F CP/MAS NMR
G. Althoff, J. Ruiz, V. Rodríguez,, G. López, J. Pérez y C. Janiak. Cryst. Eng. Comm., 2006, 8, 662-665

A Copper- and Amine-free Sonogashira Reaction of Aryl Halides Catalyzed by 1,3,5-Triaza-7-phosphaadamantane (PTA) Palladium Systems
J. Ruiz, N. Cutillas, F. López, G. López y D. Bautista. Organometallics, 2006, 25, 5768-5773.

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2007

A Novel Metal-Binding Mode of Thymine Ncleobases: N(3) and O(4) Chelation
J. Ruiz, María Dolores Villa, Venancio rodríguez, Natalia Cutillas, Consuelo Vicente, G. López and Delia Bautista. Inorg. Chem., 2007, 46, 5448-5449

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2008

Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds.
J. Ruiz, M.D. Villa, N. Cutillas, G. López, C. de Haro, D. Bautista, V. Moreno y L. Valencia. Inorg. Chem., 2008, 47, 4490-4505.

New Palladium(II) and Platinum(II) Complexes with 9-Aminoacridine: Structures, Luminiscence, Theoretical Calculations and Antitumor Activity.
José Ruiz, Julia Lorenzo,  Consuelo Vicente, Gregorio López, José María López de Luzuriaga, Miguel Monge, Francesc X. Avilés, Delia Bautista, Virtudes Moreno y Antonio Laguna. Inorg. Chem., 2008, 47, 6990-7001. Abstract

Crystal structure - solid-state CPMAS 13C NMR correlation in palladacycle pseudo-polymorphs and a vanishing polymorph.
José Ruiz, Venancio Rodríguez, Natalia Cutillas, Anke Hoffmann, Anne-Christine Chamayou, Karolina Kazmierczak y Christoph Janiak. Cryst. Eng. Comm., 2006 (en prensa).

Acetonimine and 4-Imino-2-methylpentan-2-amino Platinum(II) Complexes: Synthesis and in Vitro Antitumor Activity .
José Ruiz, Venancio Rodríguez, Natalia Cutillas, Gregorio López y Delia Bautista. Inorg. Chem., 2008

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2009

A novel ruthenium(II) arene based intercalator with potent anticancer activity .
J. Ruiz, Consuelo Vicente, C. de Haro y D. Bautista. Dalton Trans., 2009, 5071-5073. DOI: 10.1039/b907296a.

N1-Coordination in New Palladium(II) and Platinum(II) Complexes with the Model Nucleobase 9-methylhypoxanthine: First Crystal Structure and Theoretical Calculations.
José Ruiz, Natalia Cutillas, María Dolores Villa, Gregorio López, Arturo Espinosa y Delia Bautista. Dalton Trans., 2009,9637-9644. DOI: 10.1039/b915427b.

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2010

New 7-azaindole palladium and platinum complexes: crystal structures and theoretical calculations. In vitro anticancer activity of the platinum compounds.
José Ruiz, Venancio Rodríguez, Concepción de Haro, Arturo Espinosa, José Pérez y Christoph Janiak. Dalton Trans., 2010, 39, 3290-3301. DOI: 10.1039/b920854b.

Palladium(II) complexes with pentafluorophenyl ligands: structures, C6F5 fluxionality by 2D-NMR studies and pre-catalysts for the vinyl addition polymerization of norbornene.
Frederik Blank, Harald Scherer, José Ruiz, Venancio Rodríguez y Christoph Janiak. Dalton Trans., 2010, 39, 3609-3619. DOI: 10.1039/b925674a.

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2011

Novel C,N-chelate platinum(II) antitumor complexes bearing a lipophilic ethisterone pendant.
José Ruiz, Venancio Rodríguez, Natalia Cutillas, Arturo Espinosa y Michael J. Hannon. Journal of Inorganic Biochemistry, 2011, 105, 525-531. DOI: 10.1016/j.jinorgbio.2010.12.005.

Synthesis and Antiproliferative Activity of a C,N-Cycloplatinated(II) Complex with a Potentially Intercalative Anthraquinone Pendant.
José Ruiz, Consuelo Vicente, Concepción de Haro y Arturo Espinosa. Inorg. Chem. 2011, 50, 2151–2158. DOI: dx.doi.org/10.1021/ic101526h.

η5-Cyclopentadienylpalladium(II) complexes: Synthesis, characterization and use for the vinyl addition polymerization of norbornene and the copolymerization with 5-vinyl-2-norbornene or 5-ethylidene-2-norbornene.
Frederik Blank, Jana K. Vieth, José Ruiz, Venancio Rodríguez y Christoph Janiak. Journal of Organometallic Chemistry, 2011, 696, 473-487. DOI: 10.1016/j.jorganchem.2010.08.050.

A potent ruthenium(II) antitumor complex bearing a lipophilic levonorgestrel group. Ruiz José, Rodríguez Venancio, Cutillas Natalia, Espinosa Arturo, Hannon Michael J. Inorg. Chem. 2011; 50(18): 9164-71. DOI: 10.1021/ic201388n

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2012

Novel C,N-chelate rhodium(III) and iridium(III) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA. José Ruiz, Venancio Rodríguez, Natalia Cutillas, Katia G. Samper, Mercè Capdevila , Òscar Palacios and Arturo Espinosa. Dalton Trans., 2012, 41, 12847-12856. DOI: 10.1039/c2dt31654d

Studying the interactions of a platinum(II) 9-aminoacridine complex with proteins and oligonucleotides by ESI-TOF MS. Samper Katia G, Vicente Consuelo, Rodríguez Venancio, Atrian Sílvia, Cutillas Natalia, Capdevila Mercè, Ruiz José, Palacios Òscar. Dalton Trans. 2012; 41(1): 300-6. DOI: 10.1039/C1DT11506E

Novel Bis-C,N-Cyclometalated Iridium(III) Thiosemicarbazide Antitumor Complexes: Interactions with Human Serum Albumin and DNA, and Inhibition of Cathepsin B. José Ruiz, Consuelo Vicente, Concepción de Haro and Delia Bautista. Inorg. Chem. 2013, 52, 974-982. DOI: 10.1021/ic302219v

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2013

Novel C,N-chelate rhodium(III) and iridium(III) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA. José Ruiz, Venancio Rodríguez, Natalia Cutillas, Katia G. Samper, Mercè Capdevila , Òscar Palacios and Arturo Espinosa. Dalton Trans., 2012, 41, 12847-12856. DOI: 10.1039/c2dt31654d

Anticancer cyclometalated complexes of platinum group metals and gold. Natalia Cutillas, Gorakh S. Yellol, Concepción de Haro, Consuelo Vicente, Venancio Rodríguez, José Ruiz. Coordination Chemistry Reviews. 2013, 257, 19–20, 2784–2797. DOI: 10.1016/j.ccr.2013.03.024

New steroidal 7-azaindole platinum(II) antitumor complexes. Ana Zamora, Venancio Rodríguez, Natalia Cutillas, Gorakh S. Yellol, Arturo Espinosa, Katia G. Samper, Mercè Capdevila, Òscar Palacios, José Ruiz. Journal of Inorganic Biochemistry. 2013, 128, 48–56 DOI: 10.1016/j.jinorgbio.2013.07.010

On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes. Gorakh S. Yellol, Antonio Donaire, Jyoti G. Yellol, Vera Vasylyeva, Christoph Janiak and José Ruiz. Chem. Commun., 2013, 49, 11533-11535. DOI: 10.1039/C3CC46239K

Anticancer C,N-Cycloplatinated(II) Complexes Containing Fluorinated Phosphine Ligands: Synthesis, Structural Characterization, and Biological Activity. Cutillas N, Martínez A, Yellol GS, Rodríguez V, Zamora A, Pedreño M, Donaire A, Janiak C, Ruiz J. Inorg Chem. 2013, 52(23), 13529-35. DOI: 10.1021/ic401973k.

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2014

Understanding the interaction of an antitumoral platinum(II) 7-azaindolate complex with proteins and DNA. Katia G Samper, Venancio Rodríguez, Elisabeth Ortega-Carrasco, Sílvia Atrian, Jean Didier Maréchal, Natalia Cutillas, Ana Zamora, Concepción de Haro, Mercè Capdevila, José Ruiz, Oscar Palacios. Biometals, 27, 6, 1159-1177, 2014. DOI 10.1007/s10534-014-9780-1

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2015

Synthesis of 2-Pyridyl-benzimidazole Iridium(III), Ruthenium(II), and Platinum(II) Complexes. Study of the Activity as Inhibitors of Amyloid-ß Aggregation and Neurotoxicity Evaluation. Gorakh S. Yellol, Jyoti G. Yellol, Vijaya B. Kenche, Xiang Ming Liu, Kevin J. Barnham, Antonio Donaire, Christoph Janiak, and Jose Ruiz. Inorg. Chem. 2015, Vol. 54, 470-475. DOI: 10.1021/ic502119b

On the Dual Antitumor and Anti-angiogenic Activity of Organoplatinum(II) Complexes. Ana Zamora, Sergio A. Pérez, Venancio Rodríguez, Christoph Janiak, Gorakh S. Yellol, and José Ruiz. J. Med. Chem. 2015, Vol. 58, 1320-1336. DOI: 10.1021/jm501662b

Crystal structure, theoretical calculations and antimicrobial properties of [Pt(tetramethylthiourea)4] [Pt(CN)4] 4H2O. Haseeba Sadaf, Anvarhusein A. Isab, Saeed Ahmad, Arturo Espinosa, Míriam Mas-Montoya, Islam Ullah Khan, Ejaz, Seerat-ur Rehman, Muhammad Akhtar Javed Ali, Muhammad Saleem, José Ruiz, Christoph Janiak. J. Molecular Structure, 2015, Vol. 1085, 155-161. DOI: 10.1016/j.molstruc.2014.12.076

Antitumor Properties of Platinum(IV) Prodrug-Loaded Silk Fibroin Nanoparticles. A. Abel Lozano-Pérez, Ana L. Gil, Sergio A. Pérez,b Natalia Cutillas, Hajo Meyer, Mónica Pedreño, Salvador Aznar-Cervantes, Christoph Janiak, Jose Luis Cenis, and José Ruiz. Dalton Trans. 2015, Vol. 44, 13513-13521. DOI: 10.1039/C5DT00378D

In Vitro Characterization of a Novel C,N-cyclometalated Benzimidazole Ru(II) Arene Complex: Stability, Intracellular Distribution and Binding, Effect on Organic Osmolyte Homeostasis and Induction of Apoptosis. Celina Støving Dam, Sergio Alejo Perez Henarejos, Theodosia Tsolakou, Christian Alexander Segato, Bente Gammelgaard, Gorakh S. Yellol, José Ruiz, Ian Henry Lambert, Stefan Stürup. Metallomics, 2015, Vol. 7, 885-895. DOI: 10.1039/c5mt00056d

Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure-Activity Relationship Study. Yellol J, Pérez SA, Buceta A, Yellol G, Donaire A, Szumlas P, Bednarski PJ, Makhloufi G, Janiak C, Espinosa A, Ruiz J. J Med Chem. 2015, 58, 7310-7327. DOI: 10.1021/acs.jmedchem.5b01194

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2016

Highly potent extranuclear-targeted luminescent iridium(iii) antitumor agents containing benzimidazole-based ligands with a handle for functionalization. J. Yellol, S. A. Pérez, G. Yellol, J. Zajac, A. Donaire, G. Vigueras, V. Novohradsky, C. Janiak, V. Brabec, J. Ruiz, Chem. Commun., 2016, 52, 14165 - 14168. DOI: 10.1039/c6cc07909a

Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]. E. Wachter, A. Zamora, L. Nease, D. K. Heidary, J. Ruiz and E. C. Glazer, Chem. Comm., 2016, 52, 10121-10124. DOI: 10.1039/c6cc04813g

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2017

Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage. Ana Zamora, Catherine A. Denning, David K. Heidary, Erin Wachter, Leona A. Nease, José Ruiz y Edith C. Glazer. Dalton Trans. 2017, 46, 2165-2173. DOI: 10.1039/C6DT04405K

Exploring the Influence of the Aromaticity on the Anticancer and Antivascular Activities of Organoplatinum(II) Complexes. Zamora A, Pérez S.A, Rothemund M, Rodríguez V, Schobert R, Janiak C, Ruiz J. Chemistry. Eur J. 2017, 23:5614-5625. DOI: 10.1002/chem.201700717.

Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents. Novohradsky V, Zamora A, Gandioso A, Brabec V, Ruiz J, Marchán V. Chem. Commun. 2017, 53:5523-5526. DOI: 10.1039/c7cc01946g.

New Acridine Thiourea Gold(I) Anticancer Agents: Targeting the Nucleus and Inhibiting Vasculogenic Mimicry. Pérez S.A, de Haro C, Vicente C, Donaire A, Zamora A, Zajac J, Kostrhunova H, Brabec V, Bautista D, Ruiz J. ACS Chem Biol. 2017. DOI: 10.1021/acschembio.7b00090.

DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III) and Ir(III) Antitumoural Complexes and their Interaction with DNA. José Pedro Cerón-Carrasco, José Ruiz, Consuelo Vicente, Concepción de Haro, Delia Bautista, José Zúñiga, Alberto Requena. J. Chem. Theory Comput. 2017, 13, 3898–3910. DOI: 10.1021/acs.jctc.7b00139

Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action. Vojtech Novohradsky, Jyoti Yellol, Olga Stuchlikova, María Dolores Santana, Hana Kostrhunova, Gorakh Yellol, Jana Kasparkova, Delia Bautista, Jose Ruiz, Viktor Brabec. Chem. Eur. J. 2017, 23, 15294-15299. DOI: 10.1002/chem.201703581

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2018

Exploring the Effect of the Polypyridyl Ligands on Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents, Jitka Pracharova, Gloria Vigueras, Vojtech Novohradsky, Natalia Cutillas, Christoph Janiak, Hana Kostrhunova, Jana Kasparkova, José Ruiz, and Viktor Brabec. Chem. Eur. J. 2018. DOI: 10.1002/chem.201705362

Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy, Ana Zamora, Gloria Vigueras, Venancio Rodríguez, M. Dolores Santana, José Ruiz. Coord. Chem. Rev. 2018, 360, 34-76. DOI: 10.1016/j.ccr.2018.01.010