Grupo de Investigación de Metalofármacos

Universidad de Murcia

Investigador Principal

 

José Ruiz López

Catedrático de Universidad

 

MIEMBROS

José Ruiz López (C.U.)

María Dolores Santana Lario (C.U.)

Natalia Mª Sagrado Corazón Cutillas Aulló (C.E.)

María Concepción De Haro García (T.U.)

Venanacio Rodríguez Hernández (T.U.)

Consolación Vicente López (T.U.)

Francisco José Ballester Hernández (CO)

Alaba Hernández García (CO)

Antonio Linero Artiaga (CO)

Alicia Marco Calero (CO)

Enrique Ortega Forte (CO)

Mª José Piernas Muñoz (CO)

Gloria Vigueras Bautista (CO)

Pezhman Ashoo (COL)

   

Investigación

LÍNEAS

- Estudio de la interacción de metalodrogas con DNA y proteínas.

- Preparación de nuevas metalodrogas antitumorales.

PROYECTOS

- 20857/PI/18 Nuevos inhibidores metálicos de la proteosíntesis y su aplicación para el tratamiento del cáncer.

- RTI2018-096891-B-I00 Diseño y desarrollo de nuevos complejos de metales nobles luminiscentes multidiana para terapia y fototerapia de cánceres resistentes a fármacos.

- 21115/SF/19 Diseño y desarrollo de nuevos metalocomplejos luminiscentes para fototerapia de cánceres.

 

Últimos artículos

Potent anticancer activity of a novel iridium metallodrug via oncosis. Enrique Ortega-Forte, Samanta Hernández-García, Gloria Vigueras, Paula Henarejos-Escudero, Natalia Cutillas, José Ruiz & Fernando Gandía-Herrero. Cellular and Molecular Life Sciences volume 79, 510 (2022). DOI: 10.1007/s00018-022-04526-5

 

Inert Cationic Iridium(III) Complexes with Phenanthroline-based Ligands: Application in Antimicrobial Inactivation of Multidrug-Resistant Bacterial Strains. Natalia Busto, Gloria Vigueras, Natalia Cutillas, Begoña García and José Ruiz. Dalton Trans. 51, 9653-9663 (2022). DOI: 10.1039/D2DT00752E

 

Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane–Polyurea Hybrid Nanocarrier. Joaquín Bonelli, Enrique Ortega-Forte, Anna Rovira, Manel Bosch, Oriol Torres, Cristina Cuscó, Josep Rocas, José Ruiz and Vicente Marchán. Biomacromolecules, 23, 7, 2900–2913 (2022). DOI: 10.1021/acs.biomac.2c00361

 

Portada en:

INORGANIC CHEMISTRY FRONTIERS

Volume 9 | Number 10 | 21 May 2022

 

Polyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(III) metallodrugs. Joaquín Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, José Ruiz and Vicente Marchán. Inorg. Chem. Front., 9, 2123 (2022). DOI: 10.1039/D1QI01542G

 

Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent. Lenka Markova, Vojtech Novohradsky, Jana Kasparkova, José Ruiz, Viktor Brabec. Chemico-Biological Interactions, 360, 109955 (2022). DOI: 10.1016/j.cbi.2022.109955

 

COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents. Enrique Ortega-Forte, Anna Rovira, Albert Gandioso, Joaquín Bonelli, Manel Bosch, José Ruiz, and Vicente Marchán. J. Med. Chem. 64, 23, 17209–17220 (2021). DOI: 10.1021/acs.jmedchem.1c01254

 

A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death. Gloria Vigueras, Lenka Markova, Vojtech Novohradsky, Alicia Marco, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, José Ruiz and Viktor Brabec. Inorg. Chem. Front. 8(21), 4696–4711 (2021). DOI: https://doi.org/10.1039/D1QI00856K

 

Targeting translation: a promising strategy for anticancer metallodrugs. Enrique Ortega, Gloria Vigueras, Francisco José Ballester and José Ruiz. Coordination Chemistry Reviews, 446, 214129 (2021). DOI: 10.1016/j.ccr.2021.214129

 

A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy. Enrique Ortega, Cristina Pérez-Arnaiz, Venancio Rodríguez, Christoph Janiak, Natalia Busto, Begoña García and José Ruiz. European Journal of Medicinal Chemistry, 222, 113600 (2021). DOI: 10.1016/j.ejmech.2021.113600

 

A Cyclometalated Ir(III) Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells. Dr. Vojtech Novohradsky, Dr. Lenka Markova, Dr. Hana Kostrhunova, Prof.Dr. Jana Kasparkova, Prof. José Ruiz, Prof. Vicente Marchán, Prof.Dr. Viktor Brabec. Chemistry – A European Journal, 27, 33, 8547-8556 (2021). DOI: 10.1002/chem.202100568

 

Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences. Ana Zamora, Erin Wachter, María Vera, David K. Heidary, Venancio Rodríguez, Enrique Ortega, Vanesa Fernández-Espín, Christoph Janiak, Edith C. Glazer, Giampaolo Barone and José Ruiz. Inorg. Chem. 60, 4, 2178–2187 (2021). DOI: 10.1021/acs.inorgchem.0c02648

 

Novel organo-osmium(ii) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth in Caenorhabditis elegans. Enrique Ortega, Francisco J. Ballester, Alba Hernández-García, Samanta Hernández-García, M. Alejandra Guerrero-Rubio, Delia Bautista, M. Dolores Santana, Fernando Gandía-Herrero and José Ruiz. Inorg. Chem. Front. 8, 141-155 (2021). DOI: 10.1039/C9QI01704F

 

 

 

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