Grupo de Investigación de MetalofármacosUniversidad de Murcia |
Catedrático de Universidad |
MIEMBROS María Dolores Santana Lario (C.U.) Natalia Mª Sagrado Corazón Cutillas Aulló (C.E.) María Concepción De Haro García (T.U.) Venanacio Rodríguez Hernández (T.U.) Consolación Vicente López (T.U.) Francisco José Ballester Hernández (CO) Alaba Hernández García (CO) Antonio Linero Artiaga (CO) Alicia Marco Calero (CO) Enrique Ortega Forte (CO) Mª José Piernas Muñoz (CO) Gloria Vigueras Bautista (CO) Pezhman Ashoo (COL) |
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Investigación
LÍNEAS - Estudio de la interacción de metalodrogas con DNA y proteínas. - Preparación de nuevas metalodrogas antitumorales. |
PROYECTOS - PID2021-122850NB-I00 Diseño de complejos metálicos multifuncionales para la fototerapia de celulas madre tumorales. |
Últimos artículos
| Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtec Novohradsky, Delia Bautista, Lenka Markova, María Dolores Santana, Viktor Brabec and José Ruiz. J. Med. Chem. 67, 1, 691–708 (2024). DOI:10.1021/acs.jmedchem.3c01978 |  |
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A near-infrared light-activatable Ru(<scp>ii</scp>)-coumarin photosensitizer active under hypoxic conditions. Enrique Ortega-Forte, Anna Rovira, Marta López-Corrales, Alba Hernández-García, Francisco José Ballester, Eduardo Izquierdo-García, Mireia Jordà-Redondo, Manel Bosch, Santi Nonell, María Dolores Santana, José Ruiz, Vicente Marchán and Gilles Gasser. Chem. Sci. 14, 7170-7184 (2023). DOI: 10.1039/D3SC01844J |
| Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria. Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista and José Ruiz. Dalton Trans. 52, 13482-13486 (2023). DOI:10.1039/D3DT01678A |  |
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Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells. Vojtech Novohradsky, Alicia Marco, Lenka Markova, Natalia Cutillas, José Ruiz and Viktor Brabec. J. Med. Chem. 66, 14, 9766–9783 (2023). DOI: 10.1021/acs.jmedchem.3c00586 |
| Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates. Anna Rovira, Martí i Franquès, Enrique Ortega-Forte, Cormac Hally, Mireia Jordà-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesús I. Martínez, Manel Bosch, Santi Nonell, José Ruiz and Vicente Marchán. J. Med. Chem. 66, 12, 7849–7867 (2023). DOI: 10.1021/acs.jmedchem.3c00189 |  |
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Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis. Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista, Hana Kostrhunová, Vojtěch Novohradský, Viktor Brabec, José Ruiz and Jana Kašpárková. Inorg. Chem. 62, 16, 6474–6487 (2023). DOI: 10.1021/acs.inorgchem.3c00501 |
| Newly synthesized benzothiazolyl-1,2,3-triazole derivatives: Intramolecular charge transfer tuning, solvatofluorochromism and antiproliferative properties. F. J. Ballester; E. Ortega-Forte; D. Bautista; M. D. Santana; G. Barone; J. Ruiz. Dyes and Pigments, 209-A, 110905 (2023). DOI: 10.1016/j.dyepig.2022.110905 |  |
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Potent anticancer activity of a novel iridium metallodrug via oncosis. Enrique Ortega-Forte, Samanta Hernández-García, Gloria Vigueras, Paula Henarejos-Escudero, Natalia Cutillas, José Ruiz & Fernando Gandía-Herrero. Cellular and Molecular Life Sciences volume 79, 510 (2022). DOI: 10.1007/s00018-022-04526-5 |
| Inert Cationic Iridium(III) Complexes with Phenanthroline-based Ligands: Application in Antimicrobial Inactivation of Multidrug-Resistant Bacterial Strains. Natalia Busto, Gloria Vigueras, Natalia Cutillas, Begoña García and José Ruiz. Dalton Trans. 51, 9653-9663 (2022). DOI: 10.1039/D2DT00752E |  |
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Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane–Polyurea Hybrid Nanocarrier. Joaquín Bonelli, Enrique Ortega-Forte, Anna Rovira, Manel Bosch, Oriol Torres, Cristina Cuscó, Josep Rocas, José Ruiz and Vicente Marchán. Biomacromolecules, 23, 7, 2900–2913 (2022). DOI: 10.1021/acs.biomac.2c00361 |
Portada en: INORGANIC CHEMISTRY FRONTIERS Volume 9 | Number 10 | 21 May 2022 |
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Polyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(III) metallodrugs. Joaquín Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, José Ruiz and Vicente Marchán. Inorg. Chem. Front., 9, 2123 (2022). DOI: 10.1039/D1QI01542G |
| Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent. Lenka Markova, Vojtech Novohradsky, Jana Kasparkova, José Ruiz, Viktor Brabec. Chemico-Biological Interactions, 360, 109955 (2022). DOI: 10.1016/j.cbi.2022.109955 |  |
