Index
Academic staff/Senior Scientists:
Address:
Departamento
de Biología Celular e Histologia, Facultad de Biologia.
Universidad
de Murcia. 30100 Murcia. Spain.
Instituto
Murciano de Investigación Biosanitaria (IMIB). 30120 Murcia, Spain.
Phylogeny
of immunity:
Cytokines: functional characterization of IL-1b, TNFa and IFNs.
Pattern recognition receptors: functional characterization of TLRs
Prostaglandins: role of prostaglandins, (PGE2, PGD2 and PGJ2) in the regulation of inflammation
Phagocytes: role of granulocytes and macrophages in the immune response
Gut immunity: functional characterization of mast cells
Reproductive immunology: role of (xeno)estrogens in immunity
Aquaculture:
Development of oral immunostimulants and adjuvants
Development of oral vaccines
Biomedicine:
Impact of inflammation in hematopoiesis and cancer
Identification of new prognosis markers and therapeutic targets for psoriasis
Identification and characterization of new inflammasome components.
Extracurricular roles of TERC and TERT.
Identification of new prognosis markers and therapeutic targets for dyskeratosis congenita.
Postdocs
Dr.Francisca Alcaraz-Perez palcaraz@um.es
Extracurricular roles of TERC
Dr. Isabel Cabas icabas@um.es
Role of GPER1 and estrogens in immunity
Dr. Jesus
Garcia-Castillo jesusgarciacastillo@gmail.com
Extracurricular roles of TERC
Dr. Diana Garcia-Moreno dianagm@um.es
Epigenetic regulation of inflammation in zebrafish
Implementation of site directed mutagenesis by TALEN and CRISPR
Identification and functional characterization of new inflammasome components
Dr. Victoria Gomez-Abellan vga4@um.es
Role of prostaglandins in the regulation of fish immunity
Dr. María A. Lopez-Muñoz malms@um.es
Identification and validation of new therapeutic targets and prognosis markers for psoriasis.
Dr. Ana B. Perez-Oliva anabpo@um.es
Identification and functional characterization of new inflammasome components
Implementation of proteomics techniques
Modelling the impact of inflammation and oxidative stress on melanoma development using the zebrafish.
PhD
students
Joaquin
Canton joaquin.canton@um.es
Identification and validation of new therapeutic targets and prognosis markers for psoriasis.
Miriam Fernandez-Lajarin miriam.fernandez3@um.es
Regulation of skin carcinoma by TERC
Elena Gomez-Abenza elena.gomez1@um.es
Modelling the impact of inflammation on melanoma development using the zebrafish.
Fatma Hermi fatmahermi398@yahoo.fr
Phylogenetic, molecular and functional characterization of fish prostaglandin receptors
David Hernadez-Silva davidhernandezsilva@gmail.com
Identification of new small compounds to treat premature aging disorders
Amanda E. Lopez-Canovas amandaesperanza.lopez@um.es
Slaughter stress in seabream muscle quality
Elena Martinez-Balsalobre
elena.martinez20@um.es
Regulation of hematopoiesis by TERC
Francisco
J. Martinez-Morcillo franciscojavier.martinez12@um.es
Identification and validation of new therapeutic targets and prognosis markers for psoriasis.
Francisco J. Martinez-Navarro franciscojuan.martinez@um.es
Identification and validation of new therapeutic targets and prognosis markers for psoriasis.
Elena Naranjo elena.naranjo1@um.es
Role of TERC in glioblastoma
Irene Pardo-Sanchez irene.pardo1@um.es
Role of oxidative stress and inflammation in melanoma
Lola Rodriguez-Ruiz mariadolores.rodriguez10@um.es
.Impact of the inflammasome in hematopoiesis.
Master
students
Manu
Lozano juanmanuel.lozanog@um.es
.Impact of the inflammasome in hematopoiesis.
Technicians
Inmaculada Fuentes ifm@um.es
Lab manager (UMU)
Inmaculada Lopez inmalopezmaya@hotmail.com
Lab manager (IMIB)
Pedro J.
Martinez pedrojmartinez@um.es
Zebrafish facility manager (UMU)
Former lab's members
Dr. Pablo Pelegrin pablo.pelegrin@ffis.es
Dr. Jesus Garcia-Castillo jesus.garciac@umh.es
Dr. Gloria Lopez-Castejon Gloria.Lopez-Castejon@manchester.ac.uk
Dr. Elena Chaves-Pozo elena.chaves@mu.ieo.es
Dr. Ivan
Mulero ivan.mulero@um.es
Dr. Jaya Kumari jaya_kumari2005@rediffmail.com
Dr. Francisco J. Roca froca@mrc-lmb.cam.ac.uk
Dr. Patricia Castillo-Briceño patricia.castillo-briceno@univmed.fr
Dr. Iciar Muñoz iciarmunoz@um.es
Dr. Sergio
Liarte sdll1@um.es
Nicolas Gonzalez-Tejero ngm5@um.es
Ana Montalban ana.montalban-arques@medunigraz.at
Dr. Raquel Espin
respin@um.es
Dr. Diego
Angosto dangosto@um.es
Dr. Erick Garcia-Garcia dr.erick.garcia@gmail.com
Dr. Sofia de Oliveira sdeoliveira@wisc.edu
Dr. Jana
Montero jana@um.es
Dr. Sergio Candel scandel@um.es
Dr. Chiara Gabellini donegal77@gmail.com
Dr.
Han Mingming sealion1984@126.com
Dr.
Sylwia Tyrkalska tyrkalska.sylwia@gmail.com
Dr.
Jorge Galindo-Villegas jorge-galindo@um.es
Dr. Maricarmen
Rodenas mariacarmen.rodenas1@um.es
Dr. Nuria E. Gomez-Gonzalez
nuriaesther.gomez@um.es
Ana Valera anavap92@gmail.com
Sofia Ibañez sofiaibamol22@gmail.com
MULERO I, SEPULCRE MP, MESEGUER
J, GARCIA-AYALA A, MULERO V (2007). Histamine is stored in mast
cells of most evolutionarily advanced fish and regulates the fish inflammatory
response. Proc Natl Acad
Sci USA. 104: 19434-19439. Full text
ROCA FJ, MULERO I, LOPEZ-MUÑOZ A,
SEPULCRE MP, MESEGUER J, MULERO V (2008). Evolution of the inflammatory
response in vertebrates: fish TNFa is a powerful
activator of endothelial cells but hardly activates phagocytes. J Immunol
181:5071-5081. Full text
ALCARAZ-PEREZ F, MULERO V,
CAYUELA ML (2008). Application of the Dual-Luciferase Reporter Assay to the Analysis of Promoter
Activity in Zebrafish Embryos. BMC Biotechnol 8:81. Full text
SEPULCRE MP,
ALCARAZ-PÉREZ F, LÓPEZ-MUÑOZ A, ROCA FJ, MESEGUER J, CAYUELA ML, MULERO V
(2009). Evolution of LPS Recognition and Signaling: Fish TLR4 Does Not
Recognize LPS and Negatively Regulates NF-kB
Activation. J
Immunol. 182: 1836-1845 Full text
LÓPEZ-MUÑOZ A, ROCA FJ, MESEGUER
J, MULERO V (2009). New insights into the evolution of IFNs: Zebrafish group II IFNs induce a rapid and transient
expression of IFN-dependent genes and display powerful antiviral activities. J Immunol 182: 3440-3449. Full text
OLAVARRÍA VH,
SEPULCRE MP, FIGUEROA JE, MULERO V. (2010). Prolactin-induced
production of ROS and IL-1b in leukocytes from the bony
fish gilthead seabream involves Jak/Stat
and NF-kB signaling pathways. J Immunol. 185:3873-3883. Full text
LÓPEZ-MUÑOZ A SEPULCRE MP, ROCA
FJ, FIGUERAS A, MESEGUER J, MULERO V (2011). Evolutionary conserved
pro-inflammatory and antigen presentation functions of zebrafish
IFNγ revealed by transcriptomic
and functional analysis. Mol. Immunol. 48:1073-1083. Full text
GALINDO-VILLEGAS J, GARCÍA-MORENO
D, DE OLIVERIA S, MESEGUER J, MULERO V (2012). Regulation of
immunity and disease resistance by commensal microbes
and chromatin modifications during zebrafish
development. Proc Natl Acad Sci USA 109: E2605-E2614. Full text. Full text Author Summary.
COMPAN V, BAROJA-MAZO A,
LÓPEZ-CASTEJÓN G, GOMEZ AI, MARTÍNEZ CM, ANGOSTO D, MONTERO MT, HERRANZ AS,
BAZÁN E, REIMERS D, MULERO V, PELEGRÍN P (2012). Cell volume
regulation modulates NLRP3 inflammasome activation.
Immunity 37:487-500. Full text.
ESPÍN R, ROCA FJ, CANDEL S,
SEPULCRE MP, GONZÁLEZ-ROSA JM, ALCARAZ-PÉREZ F, MESEGUER J, CAYUELA ML,
MERCADER N, MULERO V (2013). TNF receptors regulate vascular homeostasis
through a caspase-8, caspase-2 and P53 apoptotic program that bypasses
caspase-3. Dis Model Mech
6:383-396. Full text.
DE OLIVEIRA S, REYES-ALDASORO CC,
CANDEL S, RENSHAW SA, MULERO V, CALADO A. (2013). Cxcl8 (IL-8)
mediates neutrophil recruitment and behavior in the zebrafish inflammatory response. J Immunol 190:4349-4359. Full text.
CABAS I, RODENAS MC, ABELLÁN E,
MESEGUER J, MULERO V, GARCÍA-AYALA A. (2013). Estrogen signaling through the
g protein-coupled estrogen receptor regulates granulocyte activation in fish. J Immunol
191:4628-4639. Full text.
ALCARAZ-PEREZ F, GARCIA-CASTILLO
J, GARCIA-MORENO D, LOPEZ-MUNOZ A, ANCHELIN M, ANGOSTO D, ZON LI, MULERO V*,
CAYUELA ML* (2014). A non-canonical function of
telomerase RNA in the regulation of developmental myelopoiesis
in zebrafish. Nat Commun 5:3228. Full text.
CANDEL S, DE
OLIVEIRA S, LÓPEZ-MUÑOZ A, GARCÍA-MORENO D, ESPÍN-PALAZÓN R, TYRKALSKA SD,
CAYUELA ML, RENSHAW SA, CORBALÁN R, VIDAL-ABARCA I, TSAI H-J, MESEGUER J,
SEPULCRE MP, MULERO V. (2014). Tnfa Signaling Through
Tnfr2 Protects Skin Against Oxidative Stress-Induced Inflammation. Plos Biol
12: e1001855. Full
text.
DE OLIVEIRA S, LÓPEZ-MUÑOZ, A,
CANDEL S, PELEGRIN P, CALADO A. MULERO V (2014). ATP modulates acute
inflammation in vivo through dual oxidase 1-derived H2O2
production and NF-κB activation. J Immunol 192:5710-5719. Full text
ESPÍN-PALAZÓN R, STACHURA DL,
CAMPBELL CA, GARCÍA-MORENO D, DEL CID N, KIM AD, CANDEL S, MESEGUER J, MULERO
V, TRAVER D. (2014). Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell 159:1070-1085. Full text
DE OLIVEIRA S, LÓPEZ-MUÑOZ, A,
MARTÍNEZ-NAVARRO FJ, GALINDO-VILLEGAS J, MULERO V, CALADO A (2014). Cxcl8-l1 and
Cxcl8-l2 are required in the zebrafish defense
against Salmonella Typhimurium. Dev Comp Immunol
49:44-48. Full text
DE OLIVEIRA S,
BOUDINOT P, CALADO A, MULERO V (2015). Duox1-Derived H2O2
Modulates Cxcl8 Expression and Neutrophil Recruitment
via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications. J Immunol
194:1523-1533. Full text
GALINDO-VILLEGAS J,
MONTALBAN-ARQUES A, LIARTE S, DE OLIVEIRA S, PARDO-PASTOR C, RUBIO-MOSCARDO F,
MESEGUER J, VALVERDE MA, MULERO V (2016). Trpv4-mediated detection of hyposmotic stress by skin keratinocytes
activates developmental immunity. J Immunol
196:738-749. Full text
TYRKALSKA SD,
CANDEL S, ANGOSTO D, GÓMEZ-ABELLÁN V, MARTÍN-SÁNCHEZ F, GARCÍA-MORENO D,
ZAPATA-PÉREZ R, SÁNCHEZ-FERRER A, SEPULCRE MP, PELEGRÍN P, MULERO V. (2016). Neutrophils mediate Salmonella Typhimurium
clearance through the GBP4 inflammasome-dependent
production of prostaglandins. Nat Commun
7:12077. Full
text
ESPIN-PALAZON E, MARTÍNEZ-LÓPEZ
A, ROCA FJ, LÓPEZ-MUÑOZ A, TYRKALSKA SD, CANDEL S, GARCÍA-MORENO D, FALCO A,
MESEGUER J, ESTEPA A, MULERO V. (2016). TNFα impairs rhabdoviral clearance by inhibiting the host autophagic antiviral response. Plos Pathog
12(6):e1005699. Full
text
CANDEL S, TYRKALSKA SD,
GARCIA-MORENO D, MESEGUER J, MULERO V (2016). Identification of
evolutionarily conserved Md1 splice variants that
regulate innate immunity through differential induction of NF-кB. J Immunol
197(4):1379-88. Full text
RODENAS MC, TAMASSIA N, CABAS I,
CALZETTI F, MESEGUER J, CASSATELLA MA, GARCÍA-AYALA A MULERO V (2017). G Protein-Coupled
Estrogen Receptor 1 Regulates Human Neutrophil
Functions. Biomed Hub 2: 454981. Full
text
RODENAS MC, CABAS I,
GÓMEZ-GONZÁLEZ NE, ARIZCUN M, MESEGUER J, MULERO V, GARCÍA-AYALA A. (2017). Estrogens Promote
the Production of Natural Neutralizing Antibodies in Fish through G
Protein-Coupled Estrogen Receptor 1. Front Immunol
8:736. Full text
ESPÍN-PALAZÓN R, WEIJTS B, MULERO
V, TRAVER D (2018). Proinflammatory
Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence. Trends Cell Biol 28:58-66. Full text
GABELLINI, C, GÓMEZ-ABENZA E,
IBÁÑEZ-MOLERO S, TUPONE MG, PÉREZ-OLIVA AB, DE OLIVEIRA S, DEL BUFALO D, MULERO
V. (2018). Interleukin 8 mediates bcl-xL-induced
enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model. Int J Cancer
142:584-596. Full text
TYRKALSKA SD, CANDEL S,
PÉREZ-OLIVA AB, VALERA A, ALCARAZ F, GARCÍA-MORENO D, CAYUELA ML, MULERO V.
(2017). Identification of an evolutionarily conserved Ankyrin domain-containing protein, Caiap,
which regulates inflammasome-dependent resistance to
bacterial infection. Front Immunol 8:1375. Full text
LÓPEZ-MUÑOZ A, NICOLÁS FE,
GARCÍA-MORENO D, PÉREZ-OLIVA AB, NAVARRO-MENDOZA MI, HERNÁNDEZ-OÑATE MA,
HERRERA-ESTRELLA A, TORRES-MARTÍNEZ S, RUIZ-VÁZQUEZ RM, GARRE V, MULERO V.
(2018). An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages. Sci Rep. 8:12802. Full text
MARTÍNEZ-NAVARRO FJ,
MARTÍNEZ-MENCHÓN T, MULERO V GALINDO-VILLEGAS J,. (2019). Models of
human psoriasis: Zebrafish the newly appointed
player. Dev Comp Immunol. 97:76-87. Full
text
GARCÍA-MORENO D, TYRKALSKA SD,
VALERA-PÉREZ A, GÓMEZ-ABENZA E, PÉREZ OLIVA AB, MULERO V. (2019). The Zebrafish: A Research Model to Understand the Evolution of
Vertebrate Immunity. Fish Shellfish Immunol.
pii: S1050-4648(19)30305-5. doi: 10.1016/j.fsi.2019.04.067. Full text
TYRKALSKA SD, PÉREZ
OLIVA AB, RODRÍGUEZ-RUIZ L, MARTÍNEZ-MORCILLO FJ, ALCARAZ-PÉREZ F,
MARTÍNEZ-NAVARRO FJ, LACHAUD C, AHMED N, SCHROEDER T, PARDO-SÁNCHEZ I, CANDEL
S, LÓPEZ-MUÑOZ A, CHOUDHURI A, ROSSMANN MP, ZON LI, CAYUELA ML, GARCÍA-MORENO
D, MULERO V. (2019). Inflammasome regulates hematopoiesis through cleavage of the master erythroid transcription factor GATA1. Immunity 51:50-63. Full
text
SEPAHI A, KRAUS A, CASADEI C,
JOHNSTON CA, GALINDO-VILLEGAS J, KELLY C, GARCÍA-MORENO D, MUÑOZ P, MULERO V,
HUERTAS M, SALINAS I. (en prensa). Olfactory sensory neurons
mediate ultrarapid antiviral immune responses in a TrkA-dependent manner. PNAS 116:12428-12436. Full text
VALERA-PÉREZ A, TYRKALSKA SD,
VIANA C, ROJAS-FERNÁNDEZ A, PELEGRÍN P, GARCÍA-MORENO D, PÉREZ-OLIVA AB, MULERO
V. (2019). WDR90 is a new component of the NLRC4 inflammasome
involved in Salmonella Typhimurium resistance. Dev Comp Immunol. doi:
10.1016/j.dci.2019.103428. Epub 2019 Jul 2. Full
text
NOVOA B, PEREIRO P, LÓPEZ-MUÑOZ
A, VARELA M, FORN-CUNÍ G, ANCHELIN M, DIOS S, ROMERO A, MARTINEZ-LÓPEZ A,
MEDINA-GALI RM, COLLADO M, COLL J, ESTEPA A, CAYUELA ML, MULERO V, FIGUERAS A
(2019). Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and
oxidative stress. Aging Cell. 2019 Jul
26:e13020. doi:
10.1111/acel.13020. Full text
GÓMEZ-ABENZA E, IBÁÑEZ-MOLERO S,
GARCÍA-MORENO D, FUENTES I, ZON LI, MIONE MC, CAYUELA ML, GABELLINI C, MULERO V
(2019). Zebrafish modeling reveals that SPINT1
regulates the aggressiveness of skin cutaneous
melanoma and its crosstalk with tumor immune microenvironment. J Exp Clin Cancer Res. 2019 Sep 13;38(1):405. doi: 10.1186/s13046-019-1389-3. Full text
Our research is funded by:
|
|
|
|
No position are
currently available.
Please contact us: vmulero@um.es